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Products:Immunology >> Immune Interventions >> Transplantation
Overview
Product name
Anti-FKBP51 antibody
See all FKBP51 products (4) ...
Description
Rabbit polyclonal to FKBP51
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Hamster, Dog, Human
Immunogen
Synthetic peptide: C(394) QKKAKEHNERDRR(407). Immunizing peptide corresponds to amino acid residues 394-407 from human FKBP 51. There is a single amino acid substitution (K396 to R396) in this domain between human and mouse FKBP 51 protein.
CQKKAKEHNE RDRR
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS, 1 mg/ml BSA, 0.05% sodium azide
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Protein Trafficking >> Nuclear Import / Export
Immunology >> Immune Interventions >> Transplantation
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Western blot - FKBP51 antibody (ab2901)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab2901 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlDetects a band of approximately 51 kDa.(By Western blot, this antibody detects an ~51 kDa protein representing FKBP 51 in HeLa cell lysate. By Western blot this antibody also detects FKBP 51 in whole tissue extracts from rat kidney and rat and mouse testes.)
IHC-P: Use at an assay dependent dilution. (PubMed: 20422297)
Target
Function
Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
Tissue specificity
Widely expressed, enriched in testis compared to other tissues.
Sequence similarities
Contains 2 PPIase FKBP-type domains.
Contains 3 TPR repeats.
Post-translational
modifications
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization
Cytoplasm. Nucleus.
Target information above from: UniProt accessionQ13451
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 51 kDa FK506 binding protein 5 antibody
- 51 kDa FK506 binding protein antibody
- 51 kDa FK506-binding protein antibody
see all
Database links
- Entrez Gene: 481759 Dog
- Entrez Gene: 2289 Human
- Entrez Gene: 14229 Mouse
- Entrez Gene: 361810 Rat
- Omim: 602623 Human
- SwissProt: Q13451 Human
- SwissProt: Q2TA84 Human
- SwissProt: Q5TGM6 Human
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Anti-FKBP51 antibody images:
References for Anti-FKBP51 antibody (ab2901)
This product has been referenced in:
- Soontornniyomkij Vet al. Short-term recognition memory impairment is associated with decreased expression of FK506 binding protein 51 in the aged mouse brain. Age (Dordr) 32:309-22 (2010). IHC-P; Mouse.Read more (PubMed: 20422297) »
- Tatro ETet al. Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. J Neuroimmune Pharmacol 4:218-26 (2009). WB; Human.Read more (PubMed: 19199039) »
See all 3 publications for this product
Publishing research using ab2901? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"