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Product name
Anti-FKBP52 antibody
See all FKBP52 products (12) ...
Description
Mouse monoclonal to FKBP52
Tested applications
WB, ICC/IF, IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment, corresponding to amino acids 301-411 of Human FKBP52
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Testosterone
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Progesterone
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Estrogen
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Corticoid
Signal Transduction >> Protein Trafficking >> Chaperones >> Other Chaperones
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Testosterone
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Corticoid
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Estrogen
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Progesterone
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microtubules >> Tubulin
Signal Transduction >> Protein Trafficking >> Chaperones >> Heat Shock Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab54991 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 52 kDa.
ICC/IF: Use a concentration of 10 µg/ml.
IHC-P: Use a concentration of 0.5 µg/ml.
Target
Function
Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
Tissue specificity
Widely expressed.
Sequence similarities
Contains 2 PPIase FKBP-type domains.
Contains 3 TPR repeats.
Domain
The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).
The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.
Post-translational
modifications
Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization
Cytoplasm > cytosol. Nucleus. Cytoplasm > cytoskeleton.
Target information above from: UniProt accessionQ02790
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- N-terminally processed antibody
- 51 kDa FK506-binding protein antibody
- 52 kDa FK506 binding protein antibody
see all
Database links
- Entrez Gene: 2288 Human
- Omim: 600611 Human
- SwissProt: Q02790 Human
- Unigene: 524183 Human
- Unigene: 713721 Human
Anti-FKBP52 antibody images:
Western blot - FKBP52 antibody (ab54991)
FKBP52 antibody (ab54991) at 1ug/lane + HeLa cell lysate at 25ug/lane.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-FKBP52 antibody(ab54991)
ab54991 at 0.5 ug/ml staining FKBP52 in human uterine cervix tissue sections by Immunohistochemistry (Formalin /PFA fixed paraffin-embedded tissue sections).
References for Anti-FKBP52 antibody (ab54991)
ab54991 has not yet been referenced specifically in any publications.
Publishing research using ab54991? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"