Anti-FLVCR1 antibody (ab26075)
Key features and details
- Goat polyclonal to FLVCR1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-FLVCR1 antibody
See all FLVCR1 primary antibodies -
Description
Goat polyclonal to FLVCR1 -
Host species
Goat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide within Human FLVCR1 aa 543-555 (C terminal). The exact sequence is proprietary.
Sequence:KTVMLSKQSESAI
Database link: Q9Y5Y0 -
General notes
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
This antibody was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab26075 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration. Detects a band of approximately 55,26 kDa (predicted molecular weight: 60 kDa).
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Notes |
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WB
Use at an assay dependent concentration. Detects a band of approximately 55,26 kDa (predicted molecular weight: 60 kDa). |
Target
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Function
Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. -
Tissue specificity
Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney. -
Involvement in disease
Defects in FLVCR1 are the cause of posterior column ataxia with retinitis pigmentosa (PCARP) [MIM:609033]. A neurodegenerative syndrome beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have no clinical or radiological evidence of cerebral or cerebellar involvement. Note=Defective neuronal heme transmembrane export due to FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the posterior spinal cord. -
Sequence similarities
Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family. -
Developmental stage
Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 28982 Human
- Omim: 609144 Human
- SwissProt: Q9Y5Y0 Human
- Unigene: 592816 Human
- Unigene: 7055 Human
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Alternative names
- Feline leukemia virus subgroup C cellular receptor antibody
- Feline leukemia virus subgroup C receptor antibody
- Feline leukemia virus subgroup C receptor related protein 1 antibody
see all
Images
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Anti-FLVCR1 antibody (ab26075) at 0.1 µg/ml + Human bone marrow tissue lysate (in RIPA buffer) at 35 µg
Predicted band size: 60 kDa
Observed band size: 55 kDa why is the actual band size different from the predicted?
Additional bands at: 26 kDa (possible isoform)Primary incubation was 1 hour. Detected by chemiluminescence.
Datasheets and documents
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Datasheet download
References (1)
ab26075 has been referenced in 1 publication.
- Rey MA et al. Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. Haematologica 93:1617-26 (2008). WB ; Human . PubMed: 18815190