Overview

  • Product nameAnti-FOXF1 antibodySee all FOXF1 primary antibodies ...
  • Description
    Rabbit polyclonal to FOXF1
  • Tested applicationsICC/IF, IHC-P, WB more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Chicken, Cow, Dog, Xenopus laevis
  • Immunogen

    Synthetic peptide: SASAALNSGA SYIKQQPLSP CNPAANPLSG SLSTHSLEQP YLHQNSHNAP AELQG, corresponding to amino acids 273-327 of FOXF1

  • Positive control
    • Fetal placental lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab23194 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF Use at an assay dependent concentration. PubMed: 21341990
IHC-P Use at an assay dependent dilution. PubMed: 20722018
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 40 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionProbable transcription activator for a number of lung-specific genes.
  • Tissue specificityLung and placenta.
  • Involvement in diseaseDefects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]. ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
  • Sequence similaritiesContains 1 fork-head DNA-binding domain.
  • DomainActivation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.
  • Cellular localizationNucleus.
  • Target information above from: UniProt accession Q12946 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • AI450827 antibody
    • FKH L5 antibody
    • FKHL 5 antibody
    • FKHL5 antibody
    • FKHL5 antibody
    • Forkhead (Drosophila) like 5 antibody
    • forkhead (Drosophila)-like 5 antibody
    • forkhead (Drosophila)-like 5 antibody
    • forkhead box F1 antibody
    • forkhead box F1 antibody
    • Forkhead box protein F1 antibody
    • Forkhead drosophila homolog like 5 antibody
    • Forkhead like 5 antibody
    • Forkhead related activator 1 antibody
    • Forkhead related protein FKHL5 antibody
    • Forkhead related transcription factor 1 antibody
    • forkhead-related activator 1 antibody
    • forkhead-related activator 1 antibody
    • Forkhead-related protein FKHL5 antibody
    • Forkhead-related transcription factor 1 antibody
    • FOX F1 antibody
    • FOXF 1 antibody
    • foxf1 antibody
    • FOXF1_HUMAN antibody
    • FREAC 1 antibody
    • FREAC-1 antibody
    • FREAC1 antibody
    • FREAC1 antibody
    • HFH 8 antibody
    • homolog-like 5 antibody
    • homolog-like 5 antibody
    • MGC105125 antibody
    see all

Anti-FOXF1 antibody images

References for Anti-FOXF1 antibody (ab23194)

This product has been referenced in:
  • Bozyk PD  et al. Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern of lung-specific gene expression. Stem Cells Dev 20:1995-2007 (2011). ICC/IF ; Human . Read more (PubMed: 21341990) »
  • Minogue BM  et al. Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation. Arthritis Rheum 62:3695-705 (2010). IHC-P ; Human . Read more (PubMed: 20722018) »

See all 2 Publications for this product

Product Wall

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Expiration date: 27th of February 2013

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