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Anti-FRS2 antibody (ab10425)

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Overview

Product name

Anti-FRS2 antibody
See all FRS2 products (3) ...

Description

Rabbit polyclonal to FRS2

Tested applications

IP, WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to amino acids 487-505 of Human FRS2alpha.

Positive control

Rat PC-12 and human HepG2 cell lysates.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 15mM Sodium Azide
Constituents: 1% BSA, 0.01M PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Signal Transduction >> Growth Factors/Hormones >> FGF

Applications

Show applications key

Our Abpromise guarantee covers the use of ab10425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    IP

     IP: Use at an assay depe...Read more →

    IP: Use at an assay dependent dilution. Use 10µg to 20ug using 3 mg RIPA lysate of mouse NIH/3T3 cells.

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    WB

     WB: 1/1000. Detects a ba...Read more →

    WB: 1/1000. Detects a band of approximately 92 , 95 kDa.

Target

Function

Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Tissue specificity

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Sequence similarities

Contains 1 IRS-type PTB domain.

Post-translational
modifications

Phosphorylated on tyrosine residues upon stimulation by NGF.
Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.

Cellular localization

Endomembrane system. Cytoplasmic, membrane-bound.

Target information above from: UniProt accessionQ8WU20 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • FGFR signaling adaptor SNT antibody
  • FGFR signalling adaptor antibody
  • FGFR substrate 2 antibody
  • FGFR-signaling adaptor SNT antibody
  • Fibroblast Growth Factor Receptor Substrate 2 antibody
  • FRS 2 antibody
  • FRS2 antibody
  • FRS2_HUMAN antibody
  • FRS2A antibody
  • FRS2alpha antibody
  • SNT 1 antibody
  • SNT antibody
  • SNT-1 antibody
  • SNT1 antibody
  • Suc 1 Associated Neurotrophic Factor Target antibody
  • Suc1 associated neurotrophic factor target 1 antibody
  • Suc1-associated neurotrophic factor target 1 antibody
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Database links

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References for Anti-FRS2 antibody (ab10425)

ab10425 has not yet been referenced specifically in any publications.

Publishing research using ab10425? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"