Factor IX protein (ab62544)
Constituents: 50% Glycerol, 50% H2O
Our Abpromise guarantee covers the use of ab62544 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- Christmas DiseaseChristmas factorCoagulant factor IX
- Coagulation factor 9Coagulation factor IXCoagulation factor IX (plasma thromboplastic component)Coagulation factor IXa heavy chainF9FA9_HUMANFactor 9Factor IX DeficiencyFactor9FactorIXFIXGLA domainHaemophilia BHEMBMGC129641MGC129642P19Plasma thromboplastic componentPlasma thromboplastin componentPTCTruncated coagulation factor IX
Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
modificationsActivated by factor XIa, which excises the activation peptide.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Factor IX protein images
References for Factor IX protein (ab62544)
ab62544 has not yet been referenced specifically in any publications.