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- Secondary antibodies
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Product name
Anti-Factor X antibody (Biotin)
See all Factor X products (12) ...
Description
Rabbit polyclonal to Factor X (Biotin)
Conjugation
Biotin
Tested applications
WB, ELISA, RIAmore details
Cross reactivity
Reacts with
Cow
Immunogen
Bovine Factor X purified from Bovine plasma.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, pH 7.5
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Blood >> Coagulation >> Extrinsic
Cardiovascular >> Blood >> Coagulation >> Intrinsic
Applications
Show applications key
Our Abpromise guarantee covers the use of ab105848 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 55 kDa.
ELISA: Use at an assay dependent dilution.
RIA: Use a concentration of 3 - 7 µg/ml.
Target
Function
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Tissue specificity
Plasma; synthesized in the liver.
Involvement in disease
Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
Sequence similarities
Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
Post-translational
modifications
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Cellular localization
Secreted.
Target information above from: UniProt accessionP00742
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Form
Cleaved into the following 3 chains: 1. Factor X light chain 2. Factor X heavy chain 3. Activated factor Xa heavy chain
Alternative names
- Activated factor Xa heavy chain antibody
- Coagulation factor X antibody
- F10 antibody
see all
Database links
References for Anti-Factor X antibody (Biotin) (ab105848)
ab105848 has not yet been referenced specifically in any publications.
Publishing research using ab105848? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"