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Anti-Factor X antibody (ab110138)

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Overview

Product name

Anti-Factor X antibody
See all Factor X products (12) ...

Description

Sheep polyclonal to Factor X

Tested applications

ELISA, IHC-P, Immunodiffusion, Immunoelectrophoresismore details

Cross reactivity

Reacts with

Human

Predicted to work with

Macaque Monkey

Immunogen

Full length native Human Factor X, purified from human plasma, activated and the active site blocked.

Positive control

Human small intestine vessels, Human liver vessels.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

pH: 7.40
Constituents: 0.238% HEPES, 0.8766% Sodium chloride, 50% Glycerol

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Blood >> Coagulation >> Extrinsic
Cardiovascular >> Blood >> Coagulation >> Intrinsic

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor X antibody (ab110138)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor X antibody (ab110138) image (enlarge)

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor X antibody (ab110138)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor X antibody (ab110138) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab110138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Tissue specificity

Plasma; synthesized in the liver.

Involvement in disease

Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.

Sequence similarities

Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.

Post-translational
modifications

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Cellular localization

Secreted.

Target information above from: UniProt accessionP00742 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Form

Cleaved into the following 3 chains: 1. Factor X light chain 2. Factor X heavy chain 3. Activated factor Xa heavy chain

Alternative names

  • Activated factor Xa heavy chain antibody
  • Coagulation factor X antibody
  • F10 antibody
  • FA10_HUMAN antibody
  • factor Xa antibody
  • FX antibody
  • FXA antibody
  • Prothrombinase antibody
  • Stuart factor antibody
  • Stuart Prower factor antibody
  • Stuart-Prower factor antibody
see all

Database links

Anti-Factor X antibody images:

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor X antibody (ab110138)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor X antibody (ab110138)

ab110138, at 5 µg/ml, staining F10 in vessels in Human small intestine by immunohistochemistry.

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor X antibody (ab110138)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor X antibody (ab110138)

ab110138, at 5 µg/ml, staining a vessel in Human liver by immunohistochemistry.

References for Anti-Factor X antibody (ab110138)

ab110138 has not yet been referenced specifically in any publications.

Publishing research using ab110138? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"