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Anti-Factor XII light chain antibody [C6B7] (ab1008)

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Overview

Product name

Anti-Factor XII light chain antibody [C6B7]

Description

Mouse monoclonal [C6B7] to Factor XII light chain

Specificity

This antibody reacts with the light chain of human Factor XII.

Tested applications

ELISA, Neutralisingmore details

Cross reactivity

Reacts with

Human

Immunogen

Purified human Factor XII.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Constituents: PBS, pH 7.2

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

C6B7

Isotype

IgG1

Research areas

Cardiovascular >> Blood >> Coagulation >> Intrinsic

Applications

Show applications key

Our Abpromise guarantee covers the use of ab1008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ELISA

     

  • Neutralising

     

Application notes

Dilute in PBS or medium which is identical to that used in the assay system.
At 100 nM, this antibody inhibits 50% of Factor XII activity.
This antibody can also be used in a coagulation assay

Target

Relevance

Coagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. Factor XII, prekallikrein, and HMW kininogen form a complex bound to an anionic surface. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.

Cellular localization

Secreted

Alternative names

  • Coagulation factor XII antibody
  • Coagulation factor XIIa light chain antibody
  • F12 antibody
  • Hageman factor antibody

Database links

References for Anti-Factor XII light chain antibody [C6B7] (ab1008)

ab1008 has not yet been referenced specifically in any publications.

Publishing research using ab1008? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"