You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »
 

Anti-Factor XIIIa antibody [AC-1A1], prediluted (ab15207)

CodeSizePriceAbpointsAvailability
    
Add to basket
 
  • -
  •   
  •   
  •   
  •  
  •   
  •   
Updating...

Overview

Product name

Anti-Factor XIIIa antibody [AC-1A1], prediluted
See all Factor XIIIa products (12) ...

Description

Mouse monoclonal [AC-1A1] to Factor XIIIa, prediluted

Specificity

This antibody reacts with Factor XIII in both reduced and nonreduced forms. It does not react with human Factor XIII B chain or human Factor XII.

Tested applications

IHC-Pmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length protein to A subunit of coagulation Factor XIII(Human).

Positive control

Capillary hemangioma, dermatofibroma, and placenta tissue.

Properties

Form

Prediluted

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS, BSA

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

AC-1A1

Isotype

IgG1

Light chain type

kappa

Research areas

Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Cardiovascular >> Blood >> Coagulation >> Common
Cardiovascular >> Blood >> Serum Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab15207 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     

Application notes

IHC-P: Ready to use. Antigen retrieval is not essential but may optimise staining.

Not tested in other applications.

Target

Function

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Involvement in disease

Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Post-translational
modifications

The activation peptide is released by thrombin.

Cellular localization

Cytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.

Target information above from: UniProt accessionP00488 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Coagulation factor XIII A chain antibody
  • Coagulation factor XIII A chain precursor antibody
  • Coagulation factor XIII A polypeptide antibody
  • Coagulation factor XIII A1 polypeptide antibody
  • Coagulation factor XIII A1 subunit antibody
  • Coagulation factor XIIIa antibody
  • F13A antibody
  • F13A_HUMAN antibody
  • F13A1 antibody
  • Factor XIIIA antibody
  • Fibrinoligase antibody
  • FXIIIA antibody
  • Protein glutamine gamma glutamyltransferase A chain antibody
  • Protein-glutamine gamma-glutamyltransferase A chain antibody
  • TGase antibody
  • Transglutaminase A chain antibody
see all

Database links

References for Anti-Factor XIIIa antibody [AC-1A1], prediluted (ab15207)

ab15207 has not yet been referenced specifically in any publications.

Publishing research using ab15207? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"