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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-Factor XIIIa antibody
See all Factor XIIIa products (12) ...
Description
Rabbit polyclonal to Factor XIIIa
Specificity
This antibody reacts with the 160 kDa (unreacted dimer) and 80 kDa (reduced monomer) protein.
Tested applications
IHC-P, IHC-Frmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant protein corresponding to subunit-A of coagulation Factor XIIIa.
Positive control
Placenta.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 1% BSA
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Cardiovascular >> Blood >> Coagulation >> Common
Cardiovascular >> Blood >> Serum Proteins
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor XIIIa antibody (ab4057)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab4057 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/25 - 1/50.Perform heat mediated antigen retrieval before commencing with IHC staining protocol.(Incubate for 30 minuts at room temperature (ABC method).)
IHC-Fr: Use at an assay dependent dilution.
Target
Function
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Involvement in disease
Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
Sequence similarities
Belongs to the transglutaminase superfamily. Transglutaminase family.
Post-translational
modifications
The activation peptide is released by thrombin.
Cellular localization
Cytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Target information above from: UniProt accessionP00488
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Coagulation factor XIII A chain antibody
- Coagulation factor XIII A chain precursor antibody
- Coagulation factor XIII A polypeptide antibody
see all
Database links
- Entrez Gene: 2162 Human
- Omim: 134570 Human
- SwissProt: P00488 Human
- SwissProt: P05160 Human
- Unigene: 335513 Human
Anti-Factor XIIIa antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Factor XIIIa antibody (ab4057)
ab4057 staining formalin fixed paraffin-embedded human bowel tumour tissue sections. The sample was subjected to heat mediated antigen retrieval in citrate buffer (pH 6.0) and blocked with 10% srum for 1 hour at 24°C, prior to incubation with the primary antibody (diluted 1/100 in milk) for 12 hours at 4°C. A biotinylated goat anti-rabbit antibody was used as the secondary.
This image is courtesy of an anonymous Abreview
References for Anti-Factor XIIIa antibody (ab4057)
ab4057 has not yet been referenced specifically in any publications.
Publishing research using ab4057? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"