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Factor XIa protein (ab62411)

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Overview

Product name

Factor XIa protein

Protein description

Full length native Factor XIa protein (purified) (Human).

Properties

Purification notes

Factor XIa was prepared by activating purified factor XI with factor XIIa. Following activation, the mixture is passed over a column of immobilized anti-factor XII to remove the factor XIIa, and further purified on heparin-Sepharose. Purity is assessed by SDS PAGE analysis.

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 50% Glycerol, 50% H2O

Concentration

Concentration information loading...

Research areas

Cardiovascular >> Blood >> Coagulation >> Intrinsic

Applications

Show applications key

Our Abpromise guarantee covers the use of ab62411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • SDS-PAGE

     
  • Functional Studies

     

Application notes

Activity was determined in a clotting assay using factor XI deficient plasma: Use at an assay dependent dilution.
SDS-PAGE: Use at an assay dependent dilution.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Protein info

Function

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

Tissue specificity

Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.

Involvement in disease

Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.

Sequence similarities

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain.

Post-translational
modifications

Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.

Cellular localization

Secreted.

Target information above from: UniProt accessionP03951 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for Factor XIa protein (ab62411)

ab62411 has not yet been referenced specifically in any publications.

Publishing research using ab62411? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"