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Anti-Factor Xa antibody (ab111171)

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Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.50
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • PurityProtein G purified
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab111171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use at an assay dependent dilution. Predicted molecular weight: 55 kDa.
ELISA ELISA: Use at an assay dependent dilution.

Target

  • FunctionFactor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
  • Tissue specificityPlasma; synthesized in the liver.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications    The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    N- and O-glycosylated.
    The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P00742 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Activated factor Xa heavy chain antibodyCoagulation factor X antibodyF10 antibody
        FA10_HUMAN antibodyFX antibodyFXA antibodyProthrombinase antibodyStuart factor antibodyStuart Prower factor antibodyStuart-Prower factor antibody
      see all

    References for Anti-Factor Xa antibody (ab111171)

    ab111171 has not yet been referenced specifically in any publications.

    Publishing research using ab111171 ? Please let us know so that we can cite the reference in this datasheet

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    Submit an Abreview for ab111171 Submit a Question for ab111171

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    I have used ab111171 and it reacts with both human and mouse protein. I was told it would not react with mouse protein, only to human protein.

    I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab61389.

    To check the status of the order please contact our ...

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    I have used ab111171 and it reacts with both human and mouse protein. I was told it would not react with mouse protein, only to human protein.

    Thank you for your enquiry.

    In the process of setting up your free replacement order for one vial of ab13858, I noticed that the product you called about was ab111171 rather than ab11171, the MDC1 antibody which we discussed. You received the vi...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"