Anti-Fas Ligand antibody [Alf1.2] (ab10511)
- Product nameAnti-Fas Ligand antibody [Alf1.2]See all Fas Ligand primary antibodies ...
- DescriptionMouse monoclonal [Alf1.2] to Fas Ligand
- Tested applicationsIP, Flow Cyt more details
- Species reactivityReacts with: Human
Recombinant soluble active extracellular domain of Human FAS-Ligand.
- EpitopeThis product specifically recognises the extracellular domain of human Fas ligand.
- General notesIf slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 15mM Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4
- Concentration information loading...
- PurityProtein A purified
- Purification notesThe antibody is purified from culture supernatant of hybridoma cells grown in a bioreactor.
- Clonality Monoclonal
- Clone numberAlf1.2
Our Abpromise guarantee covers the use of ab10511 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at an assay dependent dilution. Observed to bind an unknown 55 kDa protein (antigen = 33 kDa) during immunoprecipitation.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionCytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
- Involvement in diseaseDefects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
- Sequence similaritiesBelongs to the tumor necrosis factor family.
The soluble form derives from the membrane form by proteolytic processing.
- Cellular localizationCell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.
- ALPS1B antibodyAPO1L antibodyApoptosis (APO 1) antigen ligand 1 antibody
- Apoptosis antigen ligand 1 antibodyApoptosis antigen ligand antibodyAPT1LG1 antibodyAPTL antibodyCD178 antibodyCD178 antigen antibodyCD95 ligand antibodyCD95-L antibodyCD95L antibodyCD95L protein antibodyFAS antigen ligand antibodyFas L antibodyFas ligand (TNF superfamily member 6) antibodyFas ligand antibodyFASL antibodyFasl Fas ligand (TNF superfamily member 6) antibodyFASLG antibodyGeneralized lymphoproliferative disease antibodyGld antibodysoluble form antibodyTNF superfamily member 6 antibodyTNFL6_HUMAN antibodyTNFSF6 antibodyTumor necrosis factor (ligand) superfamily member 6 antibodyTumor necrosis factor ligand superfamily member 6 antibody
References for Anti-Fas Ligand antibody [Alf1.2] (ab10511)
This product has been referenced in:
- Drukker M et al. Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol 30:531-42 (2012). Human . Read more (PubMed: 22634564) »
- Smith D et al. Technical note: Aberrant detection of cell surface Fas ligand with anti-peptide antibodies. J Immunol 160:4159-60 (1998). Read more (PubMed: 9574514) »