Anti-Fas Ligand antibody [Alf1.2] (ab10511)

Overview

• Product nameAnti-Fas Ligand antibody [Alf1.2]See all Fas Ligand primary antibodies ...
• Description
  Mouse monoclonal [Alf1.2] to Fas Ligand
• Tested applicationsIP, Flow Cyt more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant soluble active extracellular domain of Human FAS-Ligand.

• EpitopeThis product specifically recognises the extracellular domain of human Fas ligand.
• General notesIf slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 15mM Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• PurityProtein A purified
• Purification notesThe antibody is purified from culture supernatant of hybridoma cells grown in a bioreactor.
• Clonality Monoclonal
• Clone numberAlf1.2
• IsotypeIgG1
• Research Areas
  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • T Lymphocytic Lineage

  • Immunology
  • Adaptive Immunity
  • Regulatory T Cells

  • Immunology
  • Innate Immunity
  • Cytokines
  • Necrosis Factors

  • Immunology
  • Innate Immunity
  • Cytokines
  • TNF Superfamily

  • Immunology
  • Immune System Diseases
  • Autoimmune

  • Cell Biology
  • Apoptosis
  • Extracellular Signals
  • Death Ligands

Applications

Target

• FunctionCytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
• Involvement in diseaseDefects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
• Sequence similaritiesBelongs to the tumor necrosis factor family.
• Post-translational
  modificationsN-glycosylated.
  The soluble form derives from the membrane form by proteolytic processing.
• Cellular localizationCell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.

Target information above from: UniProt accession P48023 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 356 Human
  • Omim: 134638 Human
  • SwissProt: P48023 Human
  • Unigene: 2007 Human

• Alternative names
  ALPS1B antibodyAPO1L antibodyApoptosis (APO 1) antigen ligand 1 antibody

  Apoptosis antigen ligand 1 antibodyApoptosis antigen ligand antibodyAPT1LG1 antibodyAPTL antibodyCD178 antibodyCD178 antigen antibodyCD95 ligand antibodyCD95-L antibodyCD95L antibodyCD95L protein antibodyFAS antigen ligand antibodyFas L antibodyFas ligand (TNF superfamily member 6) antibodyFas ligand antibodyFASL antibodyFasl Fas ligand (TNF superfamily member 6) antibodyFASLG antibodyGeneralized lymphoproliferative disease antibodyGld antibodysoluble form antibodyTNF superfamily member 6 antibodyTNFL6_HUMAN antibodyTNFSF6 antibodyTumor necrosis factor (ligand) superfamily member 6 antibodyTumor necrosis factor ligand superfamily member 6 antibody

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