Anti-Fas Ligand antibody [B-R17] - Azide free (ab47175)
- Product nameAnti-Fas Ligand antibody [B-R17] - Azide freeSee all Fas Ligand primary antibodies ...
- DescriptionMouse monoclonal [B-R17] to Fas Ligand - Azide free
- SpecificityAb47175 recognises the soluble antigen.
- Tested applicationsFlow Cyt more details
- Species reactivityReacts with: Human
Tissue / cell preparation (Human): FasL transfected 293T cell line
- Positive controlFas L transfected 293T cell line.
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
- Concentration information loading...
- PurityIon Exchange Chromatography
- Purification notesSterile filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free.
- Clonality Monoclonal
- Clone numberB-R17
Our Abpromise guarantee covers the use of ab47175 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Note: ab47175 blocks soluble FasL induced apoptosis
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionCytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
- Involvement in diseaseDefects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
- Sequence similaritiesBelongs to the tumor necrosis factor family.
The soluble form derives from the membrane form by proteolytic processing.
- Cellular localizationCell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.
- ALPS1B antibodyApoptosis (APO 1) antigen ligand 1 antibodyApoptosis antigen ligand antibody
- APT1LG1 antibodyAPTL antibodyCD178 antibodyCD178 antigen antibodyCD95 ligand antibodyCD95-L antibodyCD95L antibodyCD95L protein antibodyFas antigen ligand antibodyFas L antibodyFas ligand (TNF superfamily member 6) antibodyFas ligand antibodyFASL antibodyFasl Fas ligand (TNF superfamily member 6) antibodyFASLG antibodyGeneralized lymphoproliferative disease antibodyGld antibodysoluble form antibodyTNFL6_HUMAN antibodyTNFSF6 antibodyTumor necrosis factor (ligand) superfamily member 6 antibodyTumor necrosis factor ligand superfamily member 6 antibody
Anti-Fas Ligand antibody [B-R17] - Azide free images
FACS analysis of Fas Ligand expressin cells in FasL transfected 293T cell line using ab47175.