Inhibitor of SREBP (Sterol regulatory binding protein) transcription factors activation.
Cell-permeable. Inhibits activation of SREBP (Sterol regulatory binding protein) transcription factors. Blocks lipid biosynthesis and accumulation. Active in vivo.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kamisuki S et al. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem54:4923-7 (2011).
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