Anti-Ferritin Heavy Chain antibody (ab36660)
- Product nameAnti-Ferritin Heavy Chain antibodySee all Ferritin Heavy Chain primary antibodies ...
- DescriptionChicken polyclonal to Ferritin Heavy Chain
- Tested applicationsWB, ELISA more details
- Species reactivityReacts with: Mouse, Human
Synthetic peptide, corresponding to amino acids 1-182 of Human Ferritin Heavy Chain
- Positive controlELISA: Purified Human Ferritin protein.
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
- Concentration information loading...
- PurityImmunogen affinity purified
- Clonality Polyclonal
Our Abpromise guarantee covers the use of ab36660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: Use at an assay dependent dilution. Predicted molecular weight: 21 kDa.|
|ELISA||ELISA: Use a concentration of 1 µg/ml.|
- RelevanceFerritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits of two types, H (heavy; 21 kDa) and L (light; 19 kDa), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.
- Cellular localizationCytoplasmic
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Anti-Ferritin Heavy Chain antibody images
Ab36660, at a fixed concentration of 1 µg/ml, staining Ferritin heavy chain from purified Ferritin protein by ELISA. Goat anti IgY HRP was the secondary antibody. A serial dilution of the antigen was used.
References for Anti-Ferritin Heavy Chain antibody (ab36660)
This product has been referenced in:
- Barbeito AG et al. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. J Neurochem 109:1067-78 (2009). WB ; Mouse . Read more (PubMed: 19519778) »