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SDS-PAGE - Ferritin Heavy Chain protein (Human) (ab78877)
(enlarge)
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Product Name
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Ferritin Heavy Chain protein (Human)
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Product type
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Proteins and Peptides
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Peptide
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Recombinant full length human Ferritin Heavy Chain; 183 amino acids, 21 kDa. Swiss ID = P02794.
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Tested applications
(see key)
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SDS-PAGE
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Application notes
(see key)
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Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Signal Transduction >> Metabolism >> Vitamins / Minerals
Cardiovascular >> Blood >> Serum Proteins
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
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Relevance
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Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits of two types, H (heavy; 21 kDa) and L (light; 19 kDa), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 10% Glycerol, 20mM Tris, 1mM DTT, pH 7.5 Material safety datasheet (MSDS) for this product:
Glycerol MSDS
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Purification notes
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ab78877is purified using conventional chromatography techniques.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Expression system
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E. coli
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Sequence
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MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA MECALHLEKN VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKAIKELG DHVTNLRKMG APESGLAEYL FDKHTLGDSD NES
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Ferritin Heavy Chain protein (Human) is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for Ferritin Heavy Chain protein (Human) images, references, products related to ab78877 and other tools.
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Ferritin Heavy Chain protein (Human) images:
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 SDS-PAGE - Ferritin Heavy Chain protein (Human) (ab78877)
15% SDS-PAGE showing ab78877 at approximately 21kDa (3µg).
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Search PubMed (MEDLINE) for references to Ferritin Heavy Chain
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