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AbcamBiochemicals (Asc-504)

Flecainide (ab120504)

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Overview

  • Product nameFlecainide
  • Description
    Sodium channel blocker
  • Biological descriptionSodium channel blocker. Class IC antiarrhythmic agent. Inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Also inhibits cardiac ryanodine receptors. Orally-active.
  • Purity> 99%

    • Properties

  • Chemical name(RS)-N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • Molecular Weight414.34
  • Chemical structureChemical Structure
  • Molecular formulaC17H20F6N2O3
  • CAS Number54143-55-4
  • PubChem identifier3356
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 50 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESFC(F)(F)COc2cc(C(=O)NCC1CCCCN1)c(OCC(F)(F)F)cc2
  • Source

    Synthetic

  • Research Areas

    • References for Flecainide (ab120504)

    This product has been referenced in:
    • Hilliard FA  et al. Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. J Mol Cell Cardiol 48:293-301 (2010). Read more (PubMed: 19835880) »
    • Rouet R & Ducouret P Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle. J Cardiovasc Pharmacol 24:177-83 (1994). Read more (PubMed: 7526048) »
    • Singh BN  et al. The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann N Y Acad Sci 432:210-35 (1984). Read more (PubMed: 6395762) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"