Follicular Dendritic Cells antibody [ED5] (ab33781)

Product Name 

Follicular Dendritic Cells antibody [ED5]

Product type 

Primary antibodies

Description 

Mouse monoclonal [ED5] to Follicular Dendritic Cells

Immunogen 

Rat spleen cells.

Reacts with 

Rat

Does not react with 
(species key)

Ms

Tested applications 
(see key)

IHC-Fr

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IHC-Fr: 1/260.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Tags & Cell Markers >> Cell Type Markers >> Other Cell Types
Immunology >> Cell Type Markers >> Non-CD >> APC
Immunology >> Cell Type Markers >> CD >> Non-lineage

Relevance 

Follicular dendritic cells are cells that facilitate antigen recognition by B cells in follicles. This kind of dendritic cell is not bone marrow derived and is not a kind of blood cell. It is purely a resident of the follicles of secondary lymphoid organs. B cells form germinal centers around follicular dendritic cells in lymphoid organs. Dendritic cells form from monocytes, white blood cells which circulate in the body and, depending on the right signal, can turn into dendritic cells or macrophages. The monocytes in turn are formed from stem cells in the bone marrow.

ED5 staining reveals a web like pattern in B cell follicles, representing the follicular dendritic cells. Mesangial cells in the kidney are also ED5 positive.

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

ED5

Myeloma 

Sp2/0-Ag14

Isotype 

IgG1

Storage buffer 

Preservative: 0.09% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

References for Follicular Dendritic Cells antibody [ED5] (ab33781)

  This clone has been used in:

Jeurissen SH & Dijkstra CD Characteristics and functional aspects of nonlymphoid cells in rat germinal centers, recognized by two monoclonal antibodies ED5 and ED6. Eur J Immunol 16:562-8 (1986). PubMed: 3486130

If you publish research using ab33781 please let us know so that we can cite the reference on this datasheet.

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