Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Immunology >> Cell Type Markers >> Non-CD >> APC
Overview
Product name
Anti-Follicular Dendritic Cells antibody [Ki-M9R]
See all Follicular Dendritic Cells products (5) ...
Description
Mouse monoclonal [Ki-M9R] to Follicular Dendritic Cells
Specificity
ab15613 is specific for subpopulations of macrophages. The antibody specifically recognises antigen trapping macrophages of the B-cell system such as sinus lining cells and dendritic reticulum cells. It is also positive on splenic metallophils. Macrophages in T-cell areas are negative with ab15613 and none of the macrophages in nonlymphoid organs are detected by the antibody.
Tested applications
IHC-Fr, IHC-Pmore details
Cross reactivity
Reacts with
Rat
Immunogen
Peritoneal macrophages (Rat).
Epitope
ab15613 detects an epitope of a 49kD cytoplasmic antigen.
Properties
Form
Liquid
Storage instructions
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Thimerosal / Merthiolate
Constituents: PBS, 10mg/ml BSA. pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Primary antibody notes
ab15613 detects a cytoplasmic antigen in accessory B-cells which are involved in antigen trapping reactions. The antigen is only expressed in sinus lining cells of lymph nodes, in follicular dendritic cells of germinal centres, and in metallophilic cells of the spleen. Thus it seems that the antigen is associated with antigen processing cells that migrate to germinal centres to develop into follicular dendritic cells.
Clonality
Monoclonal
Clone number
Ki-M9R
Isotype
IgG1
Research areas
Tags & Cell Markers >> Cell Type Markers >> Other Cell Types
Immunology >> Cell Type Markers >> Non-CD >> APC
Applications
Show applications key
Our Abpromise guarantee covers the use of ab15613 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: Use a concentration of 5 µg/ml
IHC-P: Use at an assay dependent dilution.
Target
Relevance
Follicular dendritic cells are cells that facilitate antigen recognition by B cells in follicles. This kind of dendritic cell is not bone marrow derived and is not a kind of blood cell. It is purely a resident of the follicles of secondary lymphoid organs. B cells form germinal centers around follicular dendritic cells in lymphoid organs. Dendritic cells form from monocytes, white blood cells which circulate in the body and, depending on the right signal, can turn into dendritic cells or macrophages. The monocytes in turn are formed from stem cells in the bone marrow.
Alternative names
- FDC antibody
- FDCs antibody
- Follicular dendritic cell antibody
References for Anti-Follicular Dendritic Cells antibody [Ki-M9R] (ab15613)
ab15613 has not yet been referenced specifically in any publications.
Publishing research using ab15613? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"