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Anti-Follicular Dendritic Cells antibody [RFD1] - Dendritic Cell Marker (ab8138)

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Overview

Product name

Anti-Follicular Dendritic Cells antibody [RFD1] - Dendritic Cell Marker
See all Follicular Dendritic Cells products (5) ...

Description

Mouse monoclonal [RFD1] to Follicular Dendritic Cells - Dendritic Cell Marker

Tested applications

IHC-Frmore details

Cross reactivity

Reacts with

Human

Epitope

Recognizes an epitope with within the class II MHC complex.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Purity

Tissue culture supernatant

Primary antibody notes

In normal tissue this antibody identifies dendritic cells and a proportion of B lymphocytes. Evidence in pathological tissue and functional studies suggests it binds to an epitope expressed by antigen presenting cells. Within the macrophage/dendritic cell populations the epitope seen by RFD1 is coexpressed with RFD7 by a subset of cells that exhibit suppressive activity on T cell stimulation.

Clonality

Monoclonal

Clone number

RFD1

Isotype

IgM

Research areas

Tags & Cell Markers >> Cell Type Markers >> Other Cell Types
Immunology >> Cell Type Markers >> Non-CD >> APC

Applications

Show applications key

Our Abpromise guarantee covers the use of ab8138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-Fr

     

Application notes

IHC-Fr: Use at an assay dependent dilution.
Is unsuitable for IHC-P. It will not bind to monocytes or any cells within the granulocyte series.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Follicular dendritic cells are cells that facilitate antigen recognition by B cells in follicles. This kind of dendritic cell is not bone marrow derived and is not a kind of blood cell. It is purely a resident of the follicles of secondary lymphoid organs. B cells form germinal centers around follicular dendritic cells in lymphoid organs. Dendritic cells form from monocytes, white blood cells which circulate in the body and, depending on the right signal, can turn into dendritic cells or macrophages. The monocytes in turn are formed from stem cells in the bone marrow.

Alternative names

  • FDC antibody
  • FDCs antibody
  • Follicular dendritic cell antibody

References for Anti-Follicular Dendritic Cells antibody [RFD1] - Dendritic Cell Marker (ab8138)

This product has been referenced in:

  • Reittie JEet al. Differential recovery of phenotypically and functionally distinct circulating antigen-presenting cells after allogeneic marrow transplantation. Transplantation 45:1084-91 (1988).Read more (PubMed: 2968009) »
  • Poulter LW & Condez A The effect of intracellular parasitism on cell phenotype. Clin Exp Immunol 74:344-8 (1988).Read more (PubMed: 3069252) »

See all 3 publications for this product

Publishing research using ab8138? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"