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Product name
Forskolin
Description
Adenylyl cyclase activator
Biological description
Cell-permeable activator of adenylyl cyclase. Interacts directly with the catalytic subunit of the enzyme to increase intracellular cAMP levels. Positive inotropic, platelet anti-aggregatory and anti-hypertensive actions in vivo.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-1H-benzo[f]chromen-5-yl acetate
Molecular Weight
410.50
Chemical structure
Molecular formula
C22H34O7
CAS Number
66575-29-9
Solubility
Soluble in DMSO to 25 mM and in ethanol to 10 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Obesity >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Hypertension >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Heart disease >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Diabetes >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Cancer >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Pharmacology >> Signaling >> Inositol & cAMP signaling >> Adenylyl cyclase >> Activators
Biochemicals >> Pharmacology >> Enzymes >> Cyclase >> Adenylyl cyclase >> Activators
Biochemicals >> Chemical Type >> Biochemicals
References for Forskolin (ab120058)
This product has been referenced in:
- Awad JA et al. Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide. J Biol Chem 258:2960-5 (1983).Read more (PubMed: 6681815) »
- Seamon KB et al. Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J Med Chem 26:436-9 (1983).Read more (PubMed: 6681845) »
See all 3 publications for this product
Publishing research using ab120058? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"