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Read our guarantee »Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
Anti-Fyn antibody [FYN-01]
See all Fyn products (13) ...
Mouse monoclonal [FYN-01] to Fyn
The antibody reacts with p59fyn (Fyn), a non receptor protein tyrosine kinase (59 kDa),which belongs to the Src family of cytoplasmic tyrosine kinases.
IP, ICC, WBmore details
Reacts with
Mouse, Human
Recombinant fragment, corresponding to amino acids 7-176 of Human Fyn.
Liquid
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4
Concentration information loading...
>95% by SDS-PAGE
Purified from hybridoma culture supernatant by protein A affinity chromatography.
Monoclonal
FYN-01
IgG2b
Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Signal transducers
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Src Family
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
Our Abpromise guarantee covers the use of ab1881 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at an assay dependent dilution.
ICC: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 59 kDa.
Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Phosphorylates RUNX3.
Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.
Cell membrane. Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
Target information above from: UniProt accessionP06241
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
This product has been referenced in:
See all 3 publications for this product
Publishing research using ab1881? Please let us know so that we can cite the reference in this datasheet
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