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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
Overview
Product name
Anti-Fyn antibody [FYN-01]
See all Fyn products (13) ...
Description
Mouse monoclonal [FYN-01] to Fyn
Specificity
The antibody reacts with p59fyn (Fyn), a non receptor protein tyrosine kinase (59 kDa),which belongs to the Src family of cytoplasmic tyrosine kinases.
Tested applications
IP, ICC, WBmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Recombinant fragment, corresponding to amino acids 7-176 of Human Fyn.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
>95% by SDS-PAGE
Purification notes
Purified from hybridoma culture supernatant by protein A affinity chromatography.
Clonality
Monoclonal
Clone number
FYN-01
Isotype
IgG2b
Research areas
Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Signal transducers
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Src Family
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1881 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at an assay dependent dilution.
ICC: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 59 kDa.
Target
Function
Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Phosphorylates RUNX3.
Tissue specificity
Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.
Cellular localization
Cell membrane. Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
Target information above from: UniProt accessionP06241
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- C syn protooncogene antibody
- Fyn antibody
- FYN oncogene related to SRC FGR YES antibody
see all
Database links
- Entrez Gene: 2534 Human
- Entrez Gene: 14360 Mouse
- Omim: 137025 Human
- SwissProt: P06241 Human
- SwissProt: P39688 Mouse
- Unigene: 390567 Human
- Unigene: 4848 Mouse
References for Anti-Fyn antibody [FYN-01] (ab1881)
This product has been referenced in:
- Randriamboavonjy Vet al. AMPK {alpha}2 subunit is involved in platelet signaling, clot retraction, and thrombus stability. Blood 116:2134-40 (2010). WB; Mouse.Read more (PubMed: 20558612) »
- Mitchell LAet al. Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa. Mol Hum Reprod 14:235-43 (2008).Read more (PubMed: 18245108) »
See all 3 publications for this product
Publishing research using ab1881? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"