Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Cell Biology >> Apoptosis >> Intracellular >> Kinases
Overview
Product name
Anti-GAB1 antibody
See all GAB1 products (10) ...
Description
Rabbit polyclonal to GAB1
Specificity
ab27439 recognises GAB1.
Tested applications
WB, IHC-P, IPmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Monkey
Immunogen
A synthetic peptide from C terminal of human Gab1.
Positive control
293 cells, astrocytoma.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Signal transduction >> Other
Cancer >> Cell cycle >> Cell differentiation
Cell Biology >> Cell Cycle >> Cell differentiation
Signal Transduction >> Adapters >> Cytoplasmic
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> MAPK Pathway
Cell Biology >> Apoptosis >> Intracellular >> Kinases
-
Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - GAB1 antibody (ab27439)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab27439 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 77 kDa.( Band is known to be observed at 115kDa due to post translational modifications.)
IHC-P: 1/50Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IP: Use at an assay dependent dilution.
Target
Function
Probably involved in EGF and insulin receptor signaling.
Sequence similarities
Belongs to the GAB family.
Contains 1 PH domain.
Post-translational
modifications
Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.
Target information above from: UniProt accessionQ13480
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Gab 1 antibody
- Gab1 antibody
- Gab1 antibody
see all
Database links
- Entrez Gene: 2549 Human
- Entrez Gene: 14388 Mouse
- Entrez Gene: 361388 Rat
- Omim: 604439 Human
- SwissProt: Q13480 Human
- SwissProt: Q9QYY0 Mouse
- SwissProt: C6JUQ2 Rat
- Unigene: 618456 Human
see all
Anti-GAB1 antibody images:
Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - GAB1 antibody (ab27439)
Paraffin embedded formalin fixed human astrocytoma stained with anti Gab1 antibody (ab27439).
References for Anti-GAB1 antibody (ab27439)
ab27439 has not yet been referenced specifically in any publications.
Publishing research using ab27439? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"