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Anti-GAB2 antibody (ab79426)

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Overview

Product name

Anti-GAB2 antibody
See all GAB2 products (9) ...

Description

Rabbit polyclonal to GAB2

Tested applications

WB, ELISAmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat

Immunogen

Synthetic non-phosphopeptide derived from Human GAB2 around the phosphorylation site of tyrosine 643 (V-D-YP-V-Q).

Positive control

Extracts from Jurkat cells.

Properties

Form

Liquid

Storage instructions

Store at -20°C. Stable for 12 months at -20°C

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Signal transduction >> Other
Signal Transduction >> Adapters >> Cytoplasmic
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other

  • Western blot - GAB2 antibody (ab79426)Western blot - GAB2 antibody (ab79426) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab79426 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide1 Image

    WB

     WB: 1/500 - 1/1000.Predi...Read more →

    WB: 1/500 - 1/1000.Predicted molecular weight: 74 kDa.

  • ELISA

     ELISA: 1/40000

    ELISA: 1/40000

Target

Relevance

Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins. Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC.

Cellular localization

Cytoplasm. Cell membrane

Alternative names

  • GRB2 associated binder 2 pp100 antibody
  • GAB 2 antibody
  • Grb 2 associated binder 2 antibody
  • GRB 2 associated binding protein 2 antibody
  • Grb2 associated binder 2 antibody
  • GRB2 associated binding protein 2 antibody
  • Growth factor receptor bound protein 2 associated protein 2 antibody
  • KIAA0571 antibody
  • p97 antibody
  • PH domain containing adaptor molecule p97 antibody
  • pp100 antibody
see all

Database links

Anti-GAB2 antibody images:

  Western blot - GAB2 antibody (ab79426)

Western blot - GAB2 antibody (ab79426)

All lanes : Anti-GAB2 antibody (ab79426) at 1/500 dilution

Lane 1 : Extracts from Jurkat cells
Lane 2 : Extracts from Jurkat cells with immunizing peptide at 10 µg

Lysates/proteins at 30 µg per lane.


Predicted band size : 74 kDa
Observed band size : 90 kDa (why is the actual band size different from the predicted?)

References for Anti-GAB2 antibody (ab79426)

ab79426 has not yet been referenced specifically in any publications.

Publishing research using ab79426? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"