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Product Name
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GABA A Receptor alpha 1 antibody
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See all GABA A Receptor alpha 1 antibodies (7)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to GABA A Receptor alpha 1
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Immunogen
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Fusion protein (Rat) consisting of MBP and cytoplasmic loop sequence of the GABA-A receptor alpha 1 subunit.
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Reacts with
(species key)
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Rat
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Specificity
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This antibody reacts with the 51 kDa alpha 1 subunit of rat brain GABA A. There is no known reactivity with other GABA subunits. There is no homology with other GABA subunits.
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Tested applications
(see key)
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IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IP: Use 15 µg (59% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains).
WB: 1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 55 kDa).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; multi pass membrane protein.
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Research areas
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Neuroscience >> Neurotransmission >> Receptors / Channels >> Ligand-Gated Ion Channels >> GABA Receptors
Neuroscience >> Neurotransmitter >> Amino Acids >> GABA
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Relevance
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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at Gamma aminobutyric acid type A (GABA A) receptors. GABA A receptors are ligand gated chloride ion channels. These receptors are believed to be pentameric hetero oligomers, for which 6 subunits are currently known (alpha, beta, gamma, delta, epsilon and rho). GABA A receptors mediate the majority of fast inhibitor synaptic transmissions in the brain. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA A receptor.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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10 mM Hepes (pH7.5), 150 mM NaCl, 100 ug/ml BSA and 50% glycerol Material safety datasheet (MSDS) for this product:
Glycerol MSDS
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Form
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Liquid
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Concentration
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0.150 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GABA A Receptor alpha 1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to GABA A Receptor alpha 1
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