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Product Name
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GABA A Receptor alpha 1 antibody
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See all GABA A Receptor alpha 1 antibodies (7)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to GABA A Receptor alpha 1
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Immunogen
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Synthetic peptide (Rat).
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Reacts with
(species key)
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Rat
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Specificity
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Reacts with the 50 kDa alpha 1 subunit. There is no known reactivity with other GABA subunits.
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: 1/7000.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; multi pass membrane protein.
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Research areas
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Neuroscience >> Neurotransmission >> Receptors / Channels >> Ligand-Gated Ion Channels >> GABA Receptors
Neuroscience >> Neurotransmitter >> Amino Acids >> GABA
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Relevance
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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at Gamma aminobutyric acid type A (GABA A) receptors. GABA A receptors are ligand gated chloride ion channels. These receptors are believed to be pentameric hetero oligomers, for which 6 subunits are currently known (alpha, beta, gamma, delta, epsilon and rho). GABA A receptors mediate the majority of fast inhibitor synaptic transmissions in the brain. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA A receptor.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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n/a
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GABA A Receptor alpha 1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for GABA A Receptor alpha 1 antibody (ab8341)
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This product has been used in: (two most recent references)
Herden CJ et al. Differential effects of methylmercury on gamma-aminobutyric acid type A receptor currents in rat cerebellar granule and cerebral cortical neurons in culture. J Pharmacol Exp Ther 324:517-28 (2008). PubMed: 17977981
Brandon NJ et al. GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. J Biol Chem 275:38856-62 (2000). PubMed: 10978327
See all 4 publication references for this product.
If you publish research using ab8341 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to GABA A Receptor alpha 1
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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