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Anti-GAD65 antibody - Neuronal Marker (ab2348)

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Overview

Product name

Anti-GAD65 antibody - Neuronal Marker
See all GAD65 products (10) ...

Description

Rabbit polyclonal to GAD65 - Neuronal Marker

Specificity

This antibody reacts with a 65 kD protein, known as GAD (Glutamate Decarboxylase)

Tested applications

IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Rat, Human

Immunogen

Synthetic peptide (Human).

Positive control

Pancreas

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 1% BSA

Concentration

Concentration information loading...

Purity

Protein A purified

Primary antibody notes

Two forms of GAD exist in adults, GAD 65 and GAD 67, which are encoded by different genes. GAD 65 and GAD 67 are expressed in most GABA containing neurons. GAD 65 appears to be targeted to the membrane and nerve ending, where as GAD 67 is more widely distributed throughout the cell.

Clonality

Polyclonal

Isotype

IgG

Applications

Show applications key

Our Abpromise guarantee covers the use of ab2348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    IHC-P

     IHC-P: 1/25 - 1/50.Perfo...Read more →

    IHC-P: 1/25 - 1/50.Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

  • IHC-Fr

     IHC-Fr: 1/25 - 1/50.

    IHC-Fr: 1/25 - 1/50.

Target

Function

Catalyzes the production of GABA.

Sequence similarities

Belongs to the group II decarboxylase family.

Post-translational
modifications

Phosphorylated; which does not affect kinetic parameters or subcellular location.
Palmitoylated; which is required for presynaptic clustering.

Cellular localization

Cytoplasm > cytosol. Cytoplasmic vesicle. Cell junction > synapse > presynaptic cell membrane. Golgi apparatus membrane. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.

Target information above from: UniProt accessionQ05329 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 65 kDa glutamic acid decarboxylase antibody
  • DCE 2 antibody
  • DCE2 antibody
  • DCE2_HUMAN antibody
  • GAD 2 antibody
  • GAD 65 antibody
  • GAD-2 antibody
  • GAD-65 antibody
  • GAD2 antibody
  • Glutamate decarboxylase 2 (pancreas) antibody
  • Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa) antibody
  • Glutamate Decarboxylase 2 antibody
  • Glutamate Decarboxylase 65 antibody
  • Glutamate decarboxylase 65 kDa isoform antibody
  • Glutamic Acid Decarboxylase 2 antibody
  • Glutamic Acid Decarboxylase 65 antibody
  • MGC161605 antibody
  • MGC161607 antibody
see all

References for Anti-GAD65 antibody - Neuronal Marker (ab2348)

ab2348 has not yet been referenced specifically in any publications.

Publishing research using ab2348? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"