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Products:Neuroscience >> Neurotransmitter >> Amino Acids >> Glutamate
Overview
Product name
Anti-GAD65 antibody - Neuronal Marker
See all GAD65 products (10) ...
Description
Rabbit polyclonal to GAD65 - Neuronal Marker
Specificity
This antibody reacts with a 65 kD protein, known as GAD (Glutamate Decarboxylase)
Tested applications
IHC-P, IHC-Frmore details
Cross reactivity
Reacts with
Rat, Human
Immunogen
Synthetic peptide (Human).
Positive control
Pancreas
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 1% BSA
Concentration
Concentration information loading...
Purity
Protein A purified
Primary antibody notes
Two forms of GAD exist in adults, GAD 65 and GAD 67, which are encoded by different genes. GAD 65 and GAD 67 are expressed in most GABA containing neurons. GAD 65 appears to be targeted to the membrane and nerve ending, where as GAD 67 is more widely distributed throughout the cell.
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Metabolism
Neuroscience >> Neurotransmitter >> Amino Acids >> Glutamate
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2348 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/25 - 1/50.Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr
IHC-Fr: 1/25 - 1/50.IHC-Fr: 1/25 - 1/50.
Target
Function
Catalyzes the production of GABA.
Sequence similarities
Belongs to the group II decarboxylase family.
Post-translational
modifications
Phosphorylated; which does not affect kinetic parameters or subcellular location.
Palmitoylated; which is required for presynaptic clustering.
Cellular localization
Cytoplasm > cytosol. Cytoplasmic vesicle. Cell junction > synapse > presynaptic cell membrane. Golgi apparatus membrane. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
Target information above from: UniProt accessionQ05329
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 65 kDa glutamic acid decarboxylase antibody
- DCE 2 antibody
- DCE2 antibody
see all
Database links
- Entrez Gene: 2572 Human
- Entrez Gene: 24380 Rat
- Omim: 138275 Human
- SwissProt: Q05329 Human
- SwissProt: Q5VZ29 Human
- SwissProt: Q5VZ30 Human
- SwissProt: Q05683 Rat
- Unigene: 231829 Human
see all
References for Anti-GAD65 antibody - Neuronal Marker (ab2348)
ab2348 has not yet been referenced specifically in any publications.
Publishing research using ab2348? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"