Overview

  • Product nameAnti-GALE antibodySee all GALE primary antibodies ...
  • Description
    Mouse polyclonal to GALE
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length GALE protein (Human)

  • Positive control
    • Human colon tissue lysate. GALE transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab67389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa).

Target

  • FunctionCatalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
  • PathwayCarbohydrate metabolism; galactose metabolism.
  • Involvement in diseaseDefects in GALE are the cause of epimerase-deficiency galactosemia (EDG) [MIM:230350]; also known as galactosemia type 3. Clinical features include early-onset cataracts, liver damage, deafness and mental retardation. There are two clinically distinct forms of EDG. (1) A benign, or 'peripheral' form with no detectable GALE activity in red blood cells and characterized by mild symptoms. Some patients may suffer no symptoms beyond raised levels of galactose-1-phosphate in the blood. (2) A much rarer 'generalized' form with undetectable levels of GALE activity in all tissues and resulting in severe features such as restricted growth and mental development.
  • Sequence similaritiesBelongs to the sugar epimerase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ95174 antibody
    • FLJ97302 antibody
    • Galactose 4 epimerase UDP antibody
    • Galactowaldenase antibody
    • galE antibody
    • GALE_HUMAN antibody
    • OTTHUMP00000002991 antibody
    • OTTHUMP00000002994 antibody
    • OTTHUMP00000037931 antibody
    • OTTHUMP00000044857 antibody
    • SDR1E1 antibody
    • short chain dehydrogenase/reductase family 1E member 1 antibody
    • UDP galactose 4 epimerase antibody
    • UDP galactose 4' epimerase antibody
    • UDP glucose 4 epimerase antibody
    • UDP-galactose 4-epimerase antibody
    • UDP-glucose 4-epimerase antibody
    see all

Anti-GALE antibody images

  • Anti-GALE antibody (ab67389) at 1/500 dilution + Human colon tissue lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa
  • All lanes : Anti-GALE antibody (ab67389) at 1/500 dilution

    Lane 1 : GALE transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

References for Anti-GALE antibody (ab67389)

This product has been referenced in:
  • Deng Y  et al. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest 123:455-68 (2013). WB ; Mouse . Read more (PubMed: 23257357) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"