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Overview

  • Product nameGALE proteinSee all GALE proteins and peptides ...
  • Protein descriptionRecombinant full length Human GALE (amino acids 1-348) with N terminal His tag; 368 amino acids, MWt 40.4kDa (UniProt Q14376).
  • Uniprot accessionQ14376
  • Molecular weight40.400kDa inclusive of tags
  • Protein length348 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab96767 is purified using conventional chromatography techniques.
  • E.C. Number5.1.3.2
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 5mM DTT, 20mM Tris HCl, 1mM EDTA, pH 8.0
  • Concentration information loading...
  • SequenceMGSSHHHHHHSSGLVPRGSHMAEKVLVTGGAGYIGSHTVL ELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQK PLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQ YLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRR EALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKE QCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN PSGFGTQA
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab96767 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    MS MS: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab153824,ab155277 and ab155997.

    • Protein info

    • Alternative names
        FLJ95174FLJ97302Galactose 4 epimerase UDP
        GalactowaldenasegalEGALE_HUMANOTTHUMP00000002991OTTHUMP00000002994OTTHUMP00000037931OTTHUMP00000044857SDR1E1short chain dehydrogenase/reductase family 1E member 1UDP galactose 4 epimeraseUDP galactose 4' epimeraseUDP glucose 4 epimeraseUDP-galactose 4-epimeraseUDP-glucose 4-epimerase
      see all
  • FunctionCatalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
  • PathwayCarbohydrate metabolism; galactose metabolism.
  • Involvement in diseaseDefects in GALE are the cause of epimerase-deficiency galactosemia (EDG) [MIM:230350]; also known as galactosemia type 3. Clinical features include early-onset cataracts, liver damage, deafness and mental retardation. There are two clinically distinct forms of EDG. (1) A benign, or 'peripheral' form with no detectable GALE activity in red blood cells and characterized by mild symptoms. Some patients may suffer no symptoms beyond raised levels of galactose-1-phosphate in the blood. (2) A much rarer 'generalized' form with undetectable levels of GALE activity in all tissues and resulting in severe features such as restricted growth and mental development.
  • Sequence similaritiesBelongs to the sugar epimerase family.

    • Target information above from: UniProt accession Q14376 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    GALE protein images

    • SDS-PAGE - GALE protein (ab96767)
      SDS-PAGE - GALE protein (ab96767)
      15% SDS-PAGE showing ab96767 at approximately 40.4kDa (3µg).

    References for GALE protein (ab96767)

    ab96767 has not yet been referenced specifically in any publications.

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