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Overview
Product name
GASC1 / JMJD2C peptide
See all KDM4C / GASC1 / JMJD2C products (5) ...
Protein description
Synthetic peptide derived from within residues 450 - 550 of Human GASC1 / JMJD2C.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab27532 - GASC1 / JMJD2C antibody.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
Concentration information loading...
Applications
Application notes
This peptide can be used with studies using ab27532.
Protein info
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Tissue specificity
Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Sequence similarities
Belongs to the JHDM3 histone demethylase family.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 2 PHD-type zinc fingers.
Contains 2 Tudor domains.
Domain
The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ9H3R0
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for GASC1 / JMJD2C peptide (ab30652)
ab30652 has not yet been referenced specifically in any publications.
Publishing research using ab30652? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"