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Western blot - GATA2 antibody (ab55079)
(enlarge)
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Product Name
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GATA2 antibody
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See all GATA2 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to GATA2
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Immunogen
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Recombinant fragment, corresponding to amino acids 1-103 of Human GATA2
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Reacts with
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Hu
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Tested applications
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Developmental Biology >> Lineage specification >> Ectoderm
Cardiovascular >> Heart >> Cardiogenesis >> Transcription factors/regulators
Stem Cells >> Lineage Markers >> Ectoderm
Chromatin and Nuclear Signaling >> Transcription >> Domain Families >> Zinc Finger
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Relevance
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GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation (Briegel et al., 1993). GATA2 plays a critical role in hematopoiesis. Primitive hematopoiesis in the yolk sac of mutant mice was greatly reduced and led to severe anaemia and death. Definitive hematopoiesis, evident in fetal liver followed by maintenance in the spleen and then adult bone marrow, was also significantly affected (greater than 50-fold). These data are most consistent with GATA2 serving as a regulator of genes controlling growth factor responsiveness or proliferative capacity of early hematopoietic cells.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG2a
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GATA2 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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GATA2 antibody images:
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 Western blot - GATA2 antibody (ab55079)
Predicted band size : 50 kDa
GATA2 antibody (ab55079) at 1ug/lane + HeLa cell lysate at 25ug/lane.
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Search PubMed (MEDLINE) for references to GATA2
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GATA2 antibody - more information
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