Overview

  • Product nameAnti-GCN2 antibodySee all GCN2 primary antibodies ...
  • Description
    Rabbit polyclonal to GCN2
  • Tested applicationsWB, IHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 120-330 of Human GCN2 (BAA92576.1).

  • Positive control
    • Human brain (cortex) tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab117101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 187 kDa.
IHC-P 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionCan phosphorylate the alpha subunit of EIF2 and may mediate translational control.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
    Contains 2 protein kinase domains.
    Contains 1 RWD domain.
  • DomainKinase domain 1 is a degenerate kinase domain.
    RWD domain is reported to interact with GCN1L1.
  • Post-translational
    modifications
    Autophosphorylated on threonine residues.
  • Target information above from: UniProt accession Q9P2K8 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • E2AK4_HUMAN antibody
    • Eif2ak4 antibody
    • Eukaryotic Translation Initiation Factor 2 alpha kinase 4 antibody
    • Eukaryotic translation initiation factor 2-alpha kinase 4 antibody
    • GCN2 antibody
    • GCN2 eIF2alpha kinase antibody
    • GCN2 like protein antibody
    • GCN2-like protein antibody
    • KIAA1338 antibody
    • MGCN2 antibody
    see all

Anti-GCN2 antibody images

  • ab117101 at 1/50 staining GCN2 in Formalin-fixed, Paraffin-embedded Human brain (cortex) tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-GCN2 antibody (ab117101)

ab117101 has not yet been referenced specifically in any publications.

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