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Products:Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
Overview
Product name
Anti-GDNF Receptor alpha 1 antibody
See all GDNF Receptor alpha 1 products (7) ...
Description
Rabbit polyclonal to GDNF Receptor alpha 1
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide: TALRVKNKPLGPAG, corresponding to amino acids 369-382 of Human GFR alpha 1.
TALRVKNKPL GPAG
Positive control
Crude membrane fractions of human brain, kidney and spleen.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
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Western blot - GDNF Receptor alpha 1 antibody (ab21588)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab21588 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500Detects a band of approximately 51 kDa.
Target
Relevance
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRa from human, rat, chicken and mouse have been cloned recently. GDNFRa was also termed Ret ligand 1 (RETL1) or TGF b related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRa 1. GFRa 1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRa and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
Cellular localization
Cell Membrane
Alternative names
- TRNR1 antibody
- GDNF family receptor alpha 1 antibody
- GDNF R antibody
see all
Database links
- Entrez Gene: 2674 Human
- Entrez Gene: 14585 Mouse
- Entrez Gene: 25454 Rat
- Omim: 601496 Human
- SwissProt: P56159 Human
- SwissProt: O35246 Mouse
- SwissProt: O35252 Mouse
- SwissProt: P97785 Mouse
see all
Anti-GDNF Receptor alpha 1 antibody images:
Western blot - GDNF Receptor alpha 1 antibody (ab21588)
Western blot analysis of GFR alpha 1 in crude membranes fractions of human brain (B), liver (L), kidney (K) and spleen (S), respectively. The band at 51kD is GFR alpha 1.
References for Anti-GDNF Receptor alpha 1 antibody (ab21588)
ab21588 has not yet been referenced specifically in any publications.
Publishing research using ab21588? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"