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Western blot - GDNF Receptor alpha 1 antibody (ab21588)
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Product Name
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GDNF Receptor alpha 1 antibody
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See all GDNF Receptor alpha 1 antibodies (6)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to GDNF Receptor alpha 1
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Immunogen
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Synthetic peptide: TALRVKNKPLGPAG, corresponding to amino acids 369-382 of Human GFR alpha 1.
BLAST 'TALRVKNKPLGPAG' with  or 
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Reacts with
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Hu, Ms, Rat
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
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Recommended dilutions
WB: 1/500. Detects a band of approximately 51 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
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Crude membrane fractions of human brain, kidney and spleen.
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Cellular localization
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Cell Membrane
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Research areas
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Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
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Relevance
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Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRa from human, rat, chicken and mouse have been cloned recently. GDNFRa was also termed Ret ligand 1 (RETL1) or TGF b related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRa 1. GFRa 1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRa and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GDNF Receptor alpha 1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for GDNF Receptor alpha 1 antibody images, references, products related to ab21588 and other tools.
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GDNF Receptor alpha 1 antibody images:
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 Western blot - GDNF Receptor alpha 1 antibody (ab21588)
Western blot analysis of GFR alpha 1 in crude membranes fractions of human brain (B), liver (L), kidney (K) and spleen (S), respectively.
The band at 51kD is GFR alpha 1.
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Search PubMed (MEDLINE) for references to GDNF Receptor alpha 1
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GDNF Receptor alpha 1 antibody - more information
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Customer reviews (feedback) regarding GDNF Receptor alpha 1 antibody |
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GDNF Receptor alpha 1 antibody - related products:
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GDNF Receptor alpha 1 antibody - other tools:
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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