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Products:Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
Overview
Product name
Anti-GDNF Receptor alpha 1 antibody
See all GDNF Receptor alpha 1 products (7) ...
Description
Rabbit polyclonal to GDNF Receptor alpha 1
Specificity
GDNF Receptor alpha 1 antibody detects endogenous levels of total GDNF Receptor alpha 1 protein.
Tested applications
IHC-P, ELISAmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide derived from human GFR alpa 1 (GDNF Receptor alpha 1)
Positive control
Human brain tissue
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
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Immunohistochemistry (Paraffin-embedded sections) - GDNF Receptor alpha 1 antibody (ab53079)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab53079 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/50 - 1/100.
ELISA
ELISA: 1/5000ELISA: 1/5000
Target
Relevance
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRa from human, rat, chicken and mouse have been cloned recently. GDNFRa was also termed Ret ligand 1 (RETL1) or TGF b related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRa 1. GFRa 1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRa and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
Cellular localization
Cell Membrane
Alternative names
- TRNR1 antibody
- GDNF family receptor alpha 1 antibody
- GDNF R antibody
see all
Database links
- Entrez Gene: 2674 Human
- Entrez Gene: 14585 Mouse
- Entrez Gene: 25454 Rat
- Omim: 601496 Human
- SwissProt: P56159 Human
- SwissProt: O35246 Mouse
- SwissProt: O35252 Mouse
- SwissProt: P97785 Mouse
see all
Anti-GDNF Receptor alpha 1 antibody images:
Immunohistochemistry (Paraffin-embedded sections) - GDNF Receptor alpha 1 antibody (ab53079)
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab53079 at 1/50 dilution, with and without immunizing peptide.
References for Anti-GDNF Receptor alpha 1 antibody (ab53079)
ab53079 has not yet been referenced specifically in any publications.
Publishing research using ab53079? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"