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Anti-GDNF Receptor alpha 2 antibody [MM0309-11G34] (ab89342)

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Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution.
  • Clonality Monoclonal
  • Clone numberMM0309-11G34
  • IsotypeIgG2
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab89342 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/500 - 1/1000. Predicted molecular weight: 52 kDa.

Target

  • RelevanceGlial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Cellular localizationPlasma membrane
  • Database links
    • Alternative names
        GDNF family receptor alpha 2 antibodyGDNF receptor beta antibodyGDNFR beta antibody
        GDNFRB antibodyGFR alpha 2 antibodyGFRA 2 antibodyGFRA2 antibodyGlial cell line derived neurotrophic factor family receptor alpha2b antibodyGlial cell line derived neurotrophic factor receptor beta antibodyNeurturin receptor alpha antibodyNRTNR alpha antibodyNTNR alpha antibodyNTNRA antibodyPI linked cell surface accessory protein antibodyRET ligand 2 antibodyRETL 2 antibodyRETL2 antibodyTGF beta related neurotrophic factor receptor 2 antibodyTRN receptor GPI anchored antibodyTRNR 2 antibodyTRNR2 antibody
      see all

    References for Anti-GDNF Receptor alpha 2 antibody [MM0309-11G34] (ab89342)

    ab89342 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"