Overview

  • Product nameAnti-GDNF antibodySee all GDNF primary antibodies ...
  • Description
    Rabbit polyclonal to GDNF
  • SpecificityAb27571 recognises GDNF.
  • Tested applicationsIHC-Pmore details
  • Species reactivity
    Reacts with: Cow, Human
    Predicted to work with: Mouse, Rat, Chicken
  • Immunogen

    Synthetic peptide:

    DDLSFLDDNLVYHILRKHSA

    , corresponding to amino acids 186-205 of Human GDNF.

  • Positive control
    • Brain tumor. Hippocampus. Normal human brain.

Properties

Applications

Our Abpromise guarantee covers the use of ab27570 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 for 10 min at room temperature. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNeurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
    • Tissue specificityIn the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
    • Involvement in diseaseDefects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
      Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    • Sequence similaritiesBelongs to the TGF-beta family. GDNF subfamily.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Astrocyte derived trophic factor 1 antibody
      • Astrocyte derived trophic factor antibody
      • Astrocyte-derived trophic factor antibody
      • ATF 1 antibody
      • ATF 2 antibody
      • Atf antibody
      • ATF1 antibody
      • ATF2 antibody
      • gdnf antibody
      • GDNF_HUMAN antibody
      • Glial cell derived neurotrophic factor antibody
      • Glial Cell Line Derived Neurotrophic Factor antibody
      • Glial cell line-derived neurotrophic factor antibody
      • Glial derived neurotrophic factor antibody
      • HFB1 GDNF antibody
      • hGDNF antibody
      • HSCR3 antibody
      see all

    Anti-GDNF antibody images

    • Detection of GDNF expression in paraffin embedded formalin fixed human brain tissue section using ab27570 at 1/100 for 10 min at room temperature.

    References for Anti-GDNF antibody (ab27570)

    This product has been referenced in:
    • Lucini C  et al. Glial cell line-derived neurotrophic factor expression in the retina of adult zebrafish (Danio rerio). Neurosci Lett 429:156-60 (2007). IHC-P ; Zebrafish . Read more (PubMed: 18006155) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab27570.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"