Anti-GDNF antibody (ab27570)

Overview

• Product nameAnti-GDNF antibodySee all GDNF primary antibodies ...
• Description
  Rabbit polyclonal to GDNF
• SpecificityAb27571 recognises GDNF.
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Cow, Human
  Predicted to work with: Mouse, Rat, Chicken
• Immunogen

  Synthetic peptide: DDLSFLDDNLVYHILRKHSA, corresponding to amino acids 186-205 of Human GDNF.

  Run BLAST with Run BLAST with
• Positive controlBrain tumor. Hippocampus. Normal human brain.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.1% Sodium Azide
  Constituents: 1% BSA, 10mM PBS, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesAb27570 is afinity purified.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Developmental Biology
  • Organogenesis
  • Excretory system development
  • Kidney development

  • Neuroscience
  • Neurology process
  • Growth and Development
  • Neurotrophins

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Amyotrophic lateral sclerosis

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Parkinson's disease
  • Other

Applications

Target

• FunctionNeurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
• Tissue specificityIn the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
• Involvement in diseaseDefects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
  Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
• Sequence similaritiesBelongs to the TGF-beta family. GDNF subfamily.
• Cellular localizationSecreted.

Target information above from: UniProt accession P39905 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 2668 Human
  • Entrez Gene: 14573 Mouse
  • Entrez Gene: 25453 Rat
  • Omim: 600837 Human
  • SwissProt: P39905 Human
  • SwissProt: P48540 Mouse
  • SwissProt: Q07731 Rat
  • Unigene: 248114 Human

  • Unigene: 4679 Mouse
  • Unigene: 53970 Rat

  see all

• Alternative names
  Astrocyte derived trophic factor 1 antibodyAstrocyte derived trophic factor antibodyAstrocyte-derived trophic factor antibody

  ATF 1 antibodyATF 2 antibodyAtf antibodyATF1 antibodyATF2 antibodygdnf antibodyGDNF_HUMAN antibodyGlial cell derived neurotrophic factor antibodyGlial Cell Line Derived Neurotrophic Factor antibodyGlial cell line-derived neurotrophic factor antibodyGlial derived neurotrophic factor antibodyHFB1 GDNF antibodyhGDNF antibody

  see all

Anti-GDNF antibody images

• 

  Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - GDNF antibody (ab27570)
  Detection of GDNF expression in paraffin embedded formalin fixed human brain tissue section using ab27570 at 1/100 for 10 min at room temperature.