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Products:Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
Overview
Product name
Anti-GFR alpha 3 antibody
See all GFR alpha 3 products (3) ...
Description
Rabbit polyclonal to GFR alpha 3
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide, corresponding to amino acids 347-360 of Mouse GDNF Receptor alpha 3
Positive control
Tissue lysates of mouse kidney, liver, or heart.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19135 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Predicted molecular weight: 43 kDa.
Target
Function
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
Tissue specificity
Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
Sequence similarities
Belongs to the GDNFR family.
Post-translational
modifications
N-glycosylated.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionO60609
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- GDNF family receptor alpha 3 antibody
- GDNF family receptor alpha-3 antibody
- GDNF receptor alpha-3 antibody
see all
Database links
- Entrez Gene: 2676 Human
- Entrez Gene: 14587 Mouse
- Entrez Gene: 84422 Rat
- SwissProt: O60609 Human
- SwissProt: O35118 Mouse
- SwissProt: Q6AXR3 Rat
- Unigene: 58042 Human
- Unigene: 16520 Mouse
see all
References for Anti-GFR alpha 3 antibody (ab19135)
ab19135 has not yet been referenced specifically in any publications.
Publishing research using ab19135? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"