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Product Name
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GFR alpha 3 antibody
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See all GFR alpha 3 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to GFR alpha 3
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Immunogen
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Synthetic peptide: MGLSWSPRPPL conjugated to KLH by a Glutaraldehyde linker, corresponding to N terminal amino acids 1-11 of Mouse GFR alpha 3.
BLAST 'MGLSWSPRPPL' with  or 
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Reacts with
(species key)
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Ms, Rat
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Specificity
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Specific to GFR alpha 3. No reaction with its homologues.
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Tested applications
(see key)
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IHC-Fr, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Immunohistochemistry: 1/1,000
Western Blot: 1/500
Immunoblot: 1/500.
1 site ELISA: Not tested.
Biological Inhibition: Not tested.
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Cellular localization
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Cell Membrane
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Research areas
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Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
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Relevance
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Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphatidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta. Following the identification of GFRalpha-1 and 2, another receptor in the GFR family was identified in human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin. Thus, persephin, GFRalpha-3, and Ret PTK form a complex to transmit the persephin signal and to mediate persephin function.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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n/a
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C (add glycerol to a final volume of 50% for extra stability). Avoid repeated freeze / thaw cycles.
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Notes
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This antibody stains large neurons in dorsal root ganglia. It is also useful in western blot for rat brain.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GFR alpha 3 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to GFR alpha 3
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GFR alpha 3 antibody - more information
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