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Products:Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
Overview
Product name
Anti-GFR alpha 3 antibody
See all GFR alpha 3 products (3) ...
Description
Rabbit polyclonal to GFR alpha 3
Specificity
Specific to GFR alpha 3. No reaction with its homologues.
Tested applications
IHC-Fr, WBmore details
Cross reactivity
Reacts with
Mouse, Rat
Immunogen
Synthetic peptide: MGLSWSPRPPL conjugated to KLH by a Glutaraldehyde linker, corresponding to N terminal amino acids 1-11 of Mouse GFR alpha 3.
MGLSWSPRPP L
General notes
This antibody stains large neurons in dorsal root ganglia. It is also useful in western blot for rat brain.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C (add glycerol to a final volume of 50% for extra stability). Avoid repeated freeze / thaw cycles.
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab6171 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr
WB
Application notes
Immunohistochemistry: 1/1,000
Western Blot: 1/500
Immunoblot: 1/500.
1 site ELISA: Not tested.
Biological Inhibition: Not tested.
Target
Function
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
Tissue specificity
Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
Sequence similarities
Belongs to the GDNFR family.
Post-translational
modifications
N-glycosylated.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionO60609
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- GDNF family receptor alpha 3 antibody
- GDNF family receptor alpha-3 antibody
- GDNF receptor alpha-3 antibody
see all
Database links
- Entrez Gene: 14587 Mouse
- Entrez Gene: 84422 Rat
- SwissProt: O35118 Mouse
- SwissProt: Q6AXR3 Rat
- Unigene: 16520 Mouse
- Unigene: 15499 Rat
References for Anti-GFR alpha 3 antibody (ab6171)
ab6171 has not yet been referenced specifically in any publications.
Publishing research using ab6171? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"