GFR alpha 3 antibody (ab8028)

Product Name 

GFR alpha 3 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to GFR alpha 3

Immunogen 

Synthetic peptide, corresponding to amino acids 347-360 of Mouse GFR alpha 3.

Reacts with 
(species key)

Hu, Ms, Rat

Tested applications 
(see key)

IHC (PFA fixed), IHC-P, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
IHC-P: Use at a concentration of 10 µg/ml.
Immunohistochemistry (PFA fixed): 1/50.
WB: 1/500 - 1/1000. Predicted molecular weight: 43 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Murine kidney, liver or heart tissue lysates.

Cellular localization 

Cell Membrane

Research areas 

Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins

Relevance 

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphatidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta. Following the identification of GFRalpha-1 and 2, another receptor in the GFR family was identified in human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin. Thus, persephin, GFRalpha-3, and Ret PTK form a complex to transmit the persephin signal and to mediate persephin function.

Members of the glial cell line-derived neurotrophic factor(GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

IgG fraction

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Store at +4°C.

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GFR alpha 3 antibody images:

References for GFR alpha 3 antibody (ab8028)

  This product has been used in:

Serra MP et al. Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human hippocampus and fascia dentata. Int J Dev Neurosci 23:425-38 (2005). PubMed: 16002253
If you publish research using ab8028 please let us know so that we can cite the reference on this datasheet.

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