GFR alpha 3 peptide (ab6100)

Product Name 

GFR alpha 3 peptide

Product type 

Proteins and Peptides

Tested applications 
(see key)

BL

Application notes 
(see key)

Recommended dilutions
The peptide is used for blocking the activity of anti-GFR alpha-3 (cat. no 8028). Incubating the peptide with equal volume of antibody for 30 min at 37°C usually completely blocks the antibody activity in Western blotting.

Research areas 

Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins

Relevance 

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphatidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta. Following the identification of GFRalpha-1 and 2, another receptor in the GFR family was identified in human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin. Thus, persephin, GFRalpha-3, and Ret PTK form a complex to transmit the persephin signal and to mediate persephin function.

Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novelglycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the discovery of GFRa-1 and -2, a novel receptor in GFRa family was identified recently in human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.200 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Notes 

Stable for one year.

Sequence 

RFHRQLFSQDWADS
Amino acids 347-360 of murine GFR alpha 3

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