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Product Name
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GFR alpha 3 peptide
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Product type
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Proteins and Peptides
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Tested applications
(see key)
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BL
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Application notes
(see key)
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Recommended dilutions
The peptide is used for blocking the activity of anti-GFR alpha-3 (cat. no 8028). Incubating the peptide with equal volume of antibody for 30 min at 37°C usually completely blocks the antibody activity in Western blotting.
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Research areas
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Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins
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Relevance
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Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphatidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta. Following the identification of GFRalpha-1 and 2, another receptor in the GFR family was identified in human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin. Thus, persephin, GFRalpha-3, and Ret PTK form a complex to transmit the persephin signal and to mediate persephin function.
Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novelglycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the discovery of GFRa-1 and -2, a novel receptor in GFRa family was identified recently in human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
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GFR alpha 3 peptide (ab6100) |
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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Stable for one year.
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Sequence
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RFHRQLFSQDWADS
Amino acids 347-360 of murine GFR alpha 3
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GFR alpha 3 peptide is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to GFR alpha 3
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GFR alpha 3 peptide - more information
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Customer reviews (feedback) regarding GFR alpha 3 peptide |
Customer FAQs regarding GFR alpha 3 peptide |
Protocols for GFR alpha 3 peptide |
Price and availability of products related to GFR alpha 3 peptide |
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GFR alpha 3 peptide - related products:
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Contact Abcam with a Technical Enquiry about GFR alpha 3 peptide |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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