|
|
|
|
|
Product Name
|
GGA3 antibody
|
| |
See all GGA3 antibodies (4)...
|
|
Product type
|
Primary antibodies
|
|
Description
|
Rabbit polyclonal to GGA3
|
|
Immunogen
|
A synthetic peptide from the VHS domain of human GGA3 conjugated to an immunogenic carrier protein was used as the immunogen.
|
|
Reacts with
|
Hu
|
|
Predicted to react
(species key)
|
Ms, Rat, Chk
(Due to sequence homology)
|
|
Tested applications
(see key)
|
IHC-Fr, IHC-P, WB
|
|
|
Abreviews
|
|
|
|
Application notes
(see key)
|
Recommended dilutions
IHC-P: 1/300 - 1/2000. Antigen retrieval step is recommended.
IHC-Fr: 1/300 - 1/2000.
WB: 1/300 - 1/2000. Predicted molecular weight: 78 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
|
|
Cellular localization
|
Golgi Apparatus - trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
|
|
Research areas
|
Signal Transduction >> Protein Trafficking >> Golgi Proteins
|
|
Relevance
|
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network (TGN) and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma- adaptins. GGA3 mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Alternative splicing of this gene results in two transcript variants.
|
|
|
|
|
Database links
|
The links below go to external sites and will open in a new browser window |
|
Raised in
|
Rabbit
|
|
Clonality
|
Polyclonal
|
|
Isotype
|
IgG
|
|
Purity
|
Whole antiserum
|
|
Storage buffer
|
Preservative: None
Constituents: Whole serum
|
|
Form
|
Liquid
|
|
Concentration
|
Concentration not determined - why is this?
|
|
Storage instructions
|
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GGA3 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
| |
|
Search PubMed (MEDLINE) for references to GGA3
|
| |
GGA3 antibody - more information
|
Customer reviews (feedback) regarding GGA3 antibody |
Customer FAQs regarding GGA3 antibody |
Protocols for GGA3 antibody |
Price and availability of products related to GGA3 antibody |
| |
GGA3 antibody - related products:
|
|
|
| |
GGA3 antibody - other tools:
|
Contact Abcam with a Technical Enquiry about GGA3 antibody |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
