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Product Name 

GGA3 antibody

 

See all GGA3 antibodies (4)...

Product type 

Primary antibodies

Description 

Rabbit polyclonal to GGA3

Immunogen 

A synthetic peptide from the VHS domain of human GGA3 conjugated to an immunogenic carrier protein was used as the immunogen.

Reacts with 

Hu

Predicted to react 
(species key)

Ms, Rat, Chk
(Due to sequence homology)

Tested applications 
(see key)

IHC-Fr, IHC-P, WB


Abreviews 

Customer reviews
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Application notes 
(see key)

Recommended dilutions
IHC-P: 1/300 - 1/2000. Antigen retrieval step is recommended.
IHC-Fr: 1/300 - 1/2000.
WB: 1/300 - 1/2000. Predicted molecular weight: 78 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Golgi Apparatus - trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Research areas 

Signal Transduction >> Protein Trafficking >> Golgi Proteins

Relevance 

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network (TGN) and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma- adaptins. GGA3 mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Alternative splicing of this gene results in two transcript variants.

 

Alternative names GGA3 antibody (ab76069)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

422121    (Chicken)
23163    (Human)
260302    (Mouse)
360658    (Rat)

Omim

    

606006    (Human)

SwissProt

    

Q9NZ52    (Human)
Q8BMI3    (Mouse)

Unigene

    

87726    (Human)

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Whole antiserum

Storage buffer 

Preservative: None
Constituents: Whole serum

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GGA3 antibody is on this datasheet. But please do contact us if you would like any reassurance!


 

Search PubMed (MEDLINE) for references to GGA3

 

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GGA3 antibody - related products:

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Lysates

 

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