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Product Name
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GIP antibody [04]
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See all GIP antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [04] to GIP
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Immunogen
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Synthetic human GIP coupled to carrier. The immunogen was adsorbed onto Al(OH)3 and emulsified in Freund's incomplete adjuvant.
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Reacts with
(species key)
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Hu
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Specificity
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Ab30679 recognises GIP. It cross reacts up to 10% with PACAP and GLP2 but <0.1% with glucagon, GLP1 or VIP.
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Tested applications
(see key)
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ELISA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: 1/10000. This dilution guideline applies to glutaraldehyde linked GIP OA (molar ratio 4:1) coated at 1 mg/mL. With GIP coated directly at 2 µg/mL the dilution guideline is 1/2000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Signal Transduction >> Growth Factors/Hormones >> Hormones
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
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Relevance
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Gastric inhibitory peptide, GIP, is a 42 amino acid residue protein and is principally produced in K cells in the duodenum, jejunum and, occasionally, upper ileum. GIP may also be expressed in non intestinal tissues such as rat salivary glands. It is a potent stimulator of insulin secretion in hyperglycemia. GIP acts by binding to specific G protein coupled receptors on the pancreatic islet cell membrane. An internal domain of GIP may be responsible and that the mechanism of ligand activated signal transduction is via a wortmannin sensitive pathway.
Fusion partner: SP2/mIL6.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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04
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein A purified
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Storage buffer
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Preservative: 15mM Sodium Azide.
Constituents: 500mM Sodium chloride, 10mM phosphate buffer. pH 7.4. Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GIP antibody [04] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to GIP
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GIP antibody [04] - more information
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Customer reviews (feedback) regarding GIP antibody [04] |
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