Anti-GIRK1 antibody (ab96168)

Overview

• Product nameAnti-GIRK1 antibodySee all GIRK1 primary antibodies ...
• Description
  Rabbit polyclonal to GIRK1
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Guinea pig
• Immunogen

  Recombinant fragment, corresponding to a region within amino acids 248-501 of Human GIRK1.

• Positive controlA431, H1299, HeLa whole cells lysate, DU145 xenograft

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Heart
  • Cardiac arrhythmias

  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • Potassium Channels

Applications

Target

• FunctionThis potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
• Sequence similaritiesBelongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
• Cellular localizationMembrane.

Target information above from: UniProt accession P48549 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3760 Human
  • Entrez Gene: 16519 Mouse
  • Omim: 601534 Human
  • SwissProt: P48549 Human
  • SwissProt: P63250 Mouse
  • Unigene: 591606 Human
  • Unigene: 5127 Mouse

• Alternative names
  G protein activated inward rectifier potassium channel 1 antibodyG protein-activated inward rectifier potassium channel 1 antibodyGIRK-1 antibody

  GIRK1 antibodyInward rectifier K(+) channel Kir3.1 antibodyInwardly rectifying potassium channel KIR3.1 antibodyinwardly rectifying subfamily J member 3 antibodyIRK3 antibodyIRK3_HUMAN antibodyKcnf3 antibodyKcnj3 antibodyKGA antibodyKGB1 antibodyKir3.1 antibodyPotassium channel antibodyPotassium channel, inwardly rectifying subfamily J member 3 antibodyPotassium inwardly-rectifying channel, subfamily J, member 3 antibody

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Anti-GIRK1 antibody images

• 

  Western blot - GIRK1 antibody (ab96168)
  All lanes : Anti-GIRK1 antibody (ab96168) at 1/1000 dilution
  
  Lane 1 : A431 whole cell lysate
  Lane 2 : H1299 whole cell lysate
  Lane 3 : HeLa whole cell lysate
  
  Lysates/proteins at 30 µg per lane.
  
  
  Predicted band size : 57 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GIRK1 antibody (ab96168)
  Immunohistochemical analysis of paraffin-embedded DU145 xenograft, using ab96168 at 1:100 dilution.