Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Related products
- Secondary antibodies
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-GM-CSF Receptor alpha antibody
See all GM-CSF Receptor alpha products (6) ...
Description
Goat polyclonal to GM-CSF Receptor alpha
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein (Human).
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Mesenchymal Stem Cells >> Negative Markers
Immunology >> Innate Immunity >> Cytokines >> CSFs
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab10670 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
WB
Application notes
ELISA: Use at a concentration of 0.5 - 1.0 µg/ml. The detection limit for recombinant human GM-CSF Receptor alpha is approximately 0.3 ng/well.
WB: Use at a concentration of 0.1 - 0.2 µg/ml. The detection limit for recombinant human GM-CSF Receptor alpha is approximately 20 ng/lane under non-reducing and reducing conditions. Detects a band of approximately 80 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Involvement in disease
Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Sequence similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Cellular localization
Secreted and Cell membrane.
Target information above from: UniProt accessionP15509
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD116 antibody
- CD116 antigen antibody
- CDw116 antibody
see all
Database links
- Entrez Gene: 1438 Human
- Omim: 306250 Human
- SwissProt: P15509 Human
- Unigene: 520937 Human
References for Anti-GM-CSF Receptor alpha antibody (ab10670)
This product has been referenced in:
- Schäbitz WR et al. A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF). J Cereb Blood Flow Metab 28:29-43 (2008).Read more (PubMed: 17457367) »
See 1 publication for this product
Publishing research using ab10670? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"