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Products:Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Heterotrimeric G Proteins >> G Proteins
Overview
Product name
Anti- GNAQ+ GNA11 antibody
Description
Rabbit polyclonal to GNAQ+ GNA11
Specificity
Specific for GNAQ and GNA11. It does not recognize other non-pertussis toxin-sensitive G proteins.
Tested applications
IP, WBmore details
Cross reactivity
Reacts with
Mouse, Human
Predicted to work with
all Mammals
Immunogen
Synthetic peptide: QLNLKEYNLV conjugated to KLH, corresponding to amino acids 350-359 of Human GNA11 or 344-353 of Human GNAQ and GNA11.
QLNLKEYNLV
Positive control
NIH-3T3 cell membrane extract. Rat brain microsomal preparation.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Heterotrimeric G Proteins >> G Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab79337 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use a concentration of 5 µg/ml
WB: 1/500 - 1/2000.Predicted molecular weight: 42 kDa.
Target
Relevance
Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. GNAQ and GNA11 are alpha subunits of one of the heterotrimeric GTP-binding proteins and mediate stimulation of phospholipase C.
Cellular localization
Cytoplasm. Plasma membrane.
Alternative names
- G alpha 11 antibody
- G alpha q antibody
- G protein subunit alpha 11 antibody
see all
Database links
- Entrez Gene: 2767 Human
- Entrez Gene: 2776 Human
- Entrez Gene: 14672 Mouse
- Entrez Gene: 14682 Mouse
- Omim: 139313 Human
- Omim: 600998 Human
- SwissProt: P29992 Human
- SwissProt: P50148 Human
see all
Anti- GNAQ+ GNA11 antibody images:
Western blot - GNAQ+ GNA11 antibody (ab79337)
Anti- GNAQ+ GNA11 antibody (ab79337) at 1/1000 dilution + NIH-3T3 cell membrane extract at 20 µg
Secondary
Goat anti-Rabbit HRP-conjugated IgG at 1/5000 dilution
Predicted band size : 42 kDa
Observed band size : 42 kDa
Western blot - GNAQ+ GNA11 antibody (ab79337)
Anti- GNAQ+ GNA11 antibody (ab79337) at 1/2000 dilution + Rat brain microsomal preparation at 20 µg
Secondary
Goat anti-rabbit HRP-conjugated IgG at 1/5000 dilution
Predicted band size : 42 kDa
Observed band size : 42 kDa
References for Anti- GNAQ+ GNA11 antibody (ab79337)
ab79337 has not yet been referenced specifically in any publications.
Publishing research using ab79337? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"