Anti-GOLGA5 antibody (ab80674)

Overview

• Product nameAnti-GOLGA5 antibodySee all GOLGA5 primary antibodies ...
• Description
  Rabbit polyclonal to GOLGA5
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Cow, Dog
• Immunogen

  Synthetic peptide corresponding to a region within N terminal amino acids 108-157 (SHFVRRKKSE PDDELLFDFL NSSQKEPTGR VEIRKEKGKT PVFQSSQTSS) of human GOLGA5

  Run BLAST with Run BLAST with
• Positive control721_B golgi lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified by peptide affinity chromatography method.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Tags & Cell Markers
  • Subcellular Markers
  • Organelles
  • Golgi

Applications

Target

• FunctionInvolved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
• Tissue specificityUbiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.
• Involvement in diseaseDefects in GOLGA5 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving GOLGA5 is found in thyroid papillary carcinomas. Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene which was found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl.
• Post-translational
  modificationsHighly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.
• Cellular localizationGolgi apparatus membrane. Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.

Target information above from: UniProt accession Q8TBA6 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 510412 Cow
  • Entrez Gene: 9950 Human
  • Entrez Gene: 9950 Human
  • Entrez Gene: 9950 Human
  • Entrez Gene: 27277 Mouse
  • Entrez Gene: 299258 Rat
  • Omim: 606918 Human
  • SwissProt: A5D7A5 Cow

  • SwissProt: Q8TBA6 Human
  • SwissProt: Q8TBA6 Human
  • SwissProt: Q8TBA6 Human
  • SwissProt: Q9QYE6 Mouse
  • SwissProt: Q3ZU82 Rat
  • Unigene: 104320 Human
  • Unigene: 273370 Mouse
  • Unigene: 205745 Rat

  see all

• Alternative names
  Cell proliferation inducing gene 31 antibodyCell proliferation-inducing gene 31 protein antibodyGOGA5_HUMAN antibody

  GOLGA 5 antibodyGOLGA5 antibodyGolgi autoantigen golgin subfamily a 5 antibodyGolgi integral membrane protein 5 antibodyGolgin 84 antibodyGolgin subfamily A member 5 antibodyGolgin-84 antibodyGolgin84 antibodyGOLIM 5 antibodyGOLIM5 antibodyProtein Ret-II antibodyPTC5 antibodyRet fused gene 5 antibodyRET fused gene 5 protein antibodyRet II antibodyRet II protein antibodyRET-fused gene 5 protein antibodyRFG 5 antibodyRFG5 antibody

  see all

Anti-GOLGA5 antibody images

• 

  Western blot - GOLGA5 antibody (ab80674)
  Anti-GOLGA5 antibody (ab80674) at 1 µg/ml + 721_B cell lysate at 10 µg
  
  Secondary
  HRP conjugated anti-Rabbit IgG at 1/50000 dilution
  
  Predicted band size : 83 kDa
  Observed band size : 83 kDa