You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Anti-GPR2/CCR10 antibody (ab1661)

CodeSizePriceAbpointsAvailability
    
Add to basket
 

  • -

  •   
  •   
  •   

  •  

  •  
  •  

  •  

  •  
Updating...

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »

Overview

Product name

Anti-GPR2/CCR10 antibody
See all GPR2/CCR10 products (5) ...

Description

Goat polyclonal to GPR2/CCR10

Specificity

Peptide sequence is < 50 % identical to other mouse chemokine receptors in this region.

Tested applications

Flow Cyt, ELISA, ICC, WB, IHC-Pmore details

Cross reactivity

Reacts with

Mouse

Immunogen

Synthetic peptide: KPTEQVSWGLYSGYDEEAYSVGPLPELC, corresponding to amino acids 4-31 of Mouse CCR10.

KPTEQVSWGLYSGYDEEAYSVGPLPELC

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

Mouse lymph nodes or small intestine.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Primary antibody notes

Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR10 in particular is the receptor for the skin-associated CC chemokine CCL27 (CTACK) as well as the novel chemokine CCL28 which displays chemotactic activity for resting CD4+ and CD8+ T cells.

Clonality

Polyclonal

Isotype

IgG

Research areas

Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)

  • - CCR10 antibody (ab1661)- CCR10 antibody (ab1661) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab1661 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    Flow Cyt

      See more...Read more →

    Flow Cyt: Use 0.5µg for 106 cells.

  • ELISA

     ELISA: 1/100000.

    ELISA: 1/100000.

  • ICC

     ICC: 1/500.

    ICC: 1/500.

  • WB

     WB: 1/1000.

    WB: 1/1000.

  • IHC-P

    One star (1 Abreview) IHC-P: 1/250.

    IHC-P: 1/250.

Target

Function

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Tissue specificity

Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Cellular localization

Cell membrane.

Target information above from: UniProt accessionP46092 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • C C chemokine receptor type 10 antibody
  • C C CKR 10 antibody
  • C-C chemokine receptor type 10 antibody
  • C-C CKR-10 antibody
  • CC chemokine receptor 10 antibody
  • CC CKR 10 antibody
  • CC-CKR-10 antibody
  • CCR 10 antibody
  • CCR-10 antibody
  • CCR10 antibody
  • CCR10_HUMAN antibody
  • Chemokine (C C motif) receptor 10 antibody
  • G protein coupled receptor 2 antibody
  • G protein-coupled receptor 2 antibody
  • G-protein coupled receptor 2 antibody
  • GPR 2 antibody
  • GPR2 antibody
see all

Database links

Anti-GPR2/CCR10 antibody images:

  - CCR10 antibody (ab1661)

- CCR10 antibody (ab1661)

Immunohistochemistry using ab1661 on a section of mouse small intestine

References for Anti-GPR2/CCR10 antibody (ab1661)

This product has been referenced in:

  • Kutzler MA  et al. Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo. Gene Ther 17:72-82 (2010). Mouse.Read more (PubMed: 19847203) »
  • Cornejo MG  et al. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood 113:2746-54 (2009). IHC-P; Mouse.Read more (PubMed: 19139084) »

See all 4 publications for this product

Publishing research using ab1661? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"