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Overview

  • Product nameAnti-GRHPR antibodySee all GRHPR primary antibodies ...
  • Description
    Rabbit polyclonal to GRHPR
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, from an internal sequence of human GRHPR.

  • Positive controlY79 cell line and mouse liver tissue lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab85181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/50 - 1/100. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
ELISA ELISA: 1/1000.

Target

  • FunctionEnzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
  • Tissue specificityUbiquitous. Most abundantly expressed in the liver.
  • Involvement in diseaseDefects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
  • Sequence similaritiesBelongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

    • Target information above from: UniProt accession Q9UBQ7 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        GLXR antibodyglycerate 2 dehydrogenase antibodyGLYD antibody
        Glyoxylate reductase/hydroxypyruvate reductase antibodyGrhpr antibodyGRHPR_HUMAN antibodyOTTHUMP00000021379 antibodyOTTHUMP00000021380 antibodyOTTHUMP00000046131 antibodyPH 2 antibodyPH2 antibodyPrimary hyperoxaluria type 2 antibody
      see all

    Anti-GRHPR antibody images

    • Western blot - GRHPR antibody (ab85181)
      Western blot - GRHPR antibody (ab85181)
      Anti-GRHPR antibody (ab85181) at 1/50 dilution + Y79 cell line lysate at 35 µg

      Predicted band size : 36 kDa
      Observed band size : 36 kDa
      Additional bands at : 130 kDa,50 kDa,55 kDa,95 kDa. We are unsure as to the identity of these extra bands.
    • Western blot - GRHPR antibody (ab85181)
      Western blot - GRHPR antibody (ab85181)
      Anti-GRHPR antibody (ab85181) at 1/50 dilution + mouse liver tissue lysate at 35 µg

      Predicted band size : 36 kDa
      Observed band size : 36 kDa
      Additional bands at : 42 kDa,50 kDa,90 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-GRHPR antibody (ab85181)

    ab85181 has not yet been referenced specifically in any publications.

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